[HTML][HTML] Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells

R Augustine, P Dan, A Hasan, IM Khalaf… - Biomedicine & …, 2021 - Elsevier
Cardiovascular disease is one of the leading causes of mortality worldwide. Cardiac tissue
engineering strategies focusing on biomaterial scaffolds incorporating cells and growth …

Heterocyclic-2-thione derivatives of group 10–12 metals: Coordination versatility, activation of CS (thione) bonds and biochemical potential

TS Lobana - Coordination Chemistry Reviews, 2021 - Elsevier
Heterocyclic thione derivatives of group 10–12 metals (Ni-Pt, Cu-Au, Zn-Hg) are reviewed in
this article. A survey of relatively recent coordination compounds of these metals are …

TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions

KH Asressu, CK Chan, CC Wang - RSC advances, 2021 - pubs.rsc.org
In the process of drug discovery and development, an efficient and expedient synthetic
method for imidazole-based small molecules from commercially available and cheap …

Sox2 induces neuronal formation in the developing mammalian cochlea

C Puligilla, A Dabdoub, SD Brenowitz… - Journal of …, 2010 - Soc Neuroscience
In the cochlea, spiral ganglion neurons play a critical role in hearing as they form the relay
between mechanosensory hair cells in the inner ear and cochlear nuclei in the brainstem …

A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities

SK Ko, J Kim, DC Na, S Park, SH Park, JY Hyun… - Chemistry & biology, 2015 - cell.com
The heat shock protein HSP70 plays antiapoptotic and oncogenic roles, and thus its
inhibition has been recognized as a potential avenue for anticancer therapy. Here we …

Proteostasis regulators in cystic fibrosis: current development and future perspectives

I Brusa, E Sondo, F Falchi, N Pedemonte… - Journal of Medicinal …, 2022 - ACS Publications
In cystic fibrosis (CF), the deletion of phenylalanine 508 (F508del) in the CF transmembrane
conductance regulator (CFTR) leads to misfolding and premature degradation of the mutant …

A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator

HJ Cho, HY Gee, KH Baek, SK Ko… - Journal of the …, 2011 - ACS Publications
Cystic fibrosis transmembrane conductance regulator (CFTR) is a cell-surface anion
channel that permeates chloride and bicarbonate ions. The most frequent mutation of CFTR …

Autophagy-regulating small molecules and their therapeutic applications

KH Baek, J Park, I Shin - Chemical Society Reviews, 2012 - pubs.rsc.org
Autophagy or self-eating is a complicated cellular process that is involved in protein and
organelle digestion occurring via a lysosome-dependent pathway. This process is of great …

Catalytic Synthesis of 1,2,4,5‐Tetrasubstituted 1H‐Imidazole Derivatives: State of the Art

R Rossi, G Angelici, G Casotti… - … Synthesis & Catalysis, 2019 - Wiley Online Library
Tetrasubstituted 1H‐imidazoles are a large family of heteroarene derivatives that are known
to include natural products isolated from marine sponges and synthetic compounds …

Neurogenesis-on-Chip: Electric field modulated transdifferentiation of human mesenchymal stem cell and mouse muscle precursor cell coculture

S Naskar, V Kumaran, YS Markandeya, B Mehta… - Biomaterials, 2020 - Elsevier
A number of bioengineering strategies, using biophysical stimulation, are being explored to
guide the human mesenchymal stem cells (hMScs) into different lineages. In this context, we …