RNA dependent RNA polymerases: insights from structure, function and evolution

S Venkataraman, BVLS Prasad, R Selvarajan - Viruses, 2018 - mdpi.com
RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA
viruses that is indispensable for replicating the genome as well as for carrying out …

Chromogenic/fluorogenic ensemble chemosensing systems

J Wu, B Kwon, W Liu, EV Anslyn, P Wang… - Chemical …, 2015 - ACS Publications
Nature has endowed human beings with many useful functions, by virtue of supramolecular
chemistry. As is well-known, nature can self-assemble relatively small molecular precursors …

Common and unique features of viral RNA-dependent polymerases

AJW Te Velthuis - Cellular and molecular life sciences, 2014 - Springer
Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average,
these pathogens share little sequence similarity and use different replication and …

The dengue virus NS5 protein as a target for drug discovery

SP Lim, CG Noble, PY Shi - Antiviral research, 2015 - Elsevier
The non-structural protein 5 (NS5) of flaviviruses is the most conserved amongst the viral
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …

Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2

A Shannon, B Canard - Antiviral Research, 2023 - Elsevier
Nucleoside/tide analogues (NAs) have long been used in the fight against viral diseases,
and now present a promising option for the treatment of COVID-19. Once activated to the 5 …

Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation

B Shu, P Gong - Proceedings of the National Academy of …, 2016 - National Acad Sciences
Viral RNA-dependent RNA polymerases (RdRPs) play essential roles in viral genome
replication and transcription. We previously reported several structural states of the …

RNA polymerase II transcription: structure and mechanism

X Liu, DA Bushnell, RD Kornberg - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
A minimal RNA polymerase II (pol II) transcription system comprises the polymerase and five
general transcription factors (GTFs) TFIIB,-D,-E,-F, and-H. The addition of Mediator enables …

[HTML][HTML] Nidovirus RNA polymerases: complex enzymes handling exceptional RNA genomes

CC Posthuma, AJW Te Velthuis, EJ Snijder - Virus research, 2017 - Elsevier
Coronaviruses and arteriviruses are distantly related human and animal pathogens that
belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus …

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

KE Zahn, AM Averill, P Aller, RD Wood… - Nature structural & …, 2015 - nature.com
DNA polymerase θ protects against genomic instability via an alternative end-joining repair
pathway for DNA double-strand breaks. Polymerase θ is overexpressed in breast, lung and …

Dengue virus non-structural protein 5

A El Sahili, J Lescar - Viruses, 2017 - mdpi.com
The World Health Organization estimates that the yearly number of dengue cases averages
390 million. This mosquito-borne virus disease is endemic in over 100 countries and will …