RNA dependent RNA polymerases: insights from structure, function and evolution
RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA
viruses that is indispensable for replicating the genome as well as for carrying out …
viruses that is indispensable for replicating the genome as well as for carrying out …
Chromogenic/fluorogenic ensemble chemosensing systems
J Wu, B Kwon, W Liu, EV Anslyn, P Wang… - Chemical …, 2015 - ACS Publications
Nature has endowed human beings with many useful functions, by virtue of supramolecular
chemistry. As is well-known, nature can self-assemble relatively small molecular precursors …
chemistry. As is well-known, nature can self-assemble relatively small molecular precursors …
Common and unique features of viral RNA-dependent polymerases
AJW Te Velthuis - Cellular and molecular life sciences, 2014 - Springer
Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average,
these pathogens share little sequence similarity and use different replication and …
these pathogens share little sequence similarity and use different replication and …
The dengue virus NS5 protein as a target for drug discovery
The non-structural protein 5 (NS5) of flaviviruses is the most conserved amongst the viral
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …
Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2
Nucleoside/tide analogues (NAs) have long been used in the fight against viral diseases,
and now present a promising option for the treatment of COVID-19. Once activated to the 5 …
and now present a promising option for the treatment of COVID-19. Once activated to the 5 …
Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation
B Shu, P Gong - Proceedings of the National Academy of …, 2016 - National Acad Sciences
Viral RNA-dependent RNA polymerases (RdRPs) play essential roles in viral genome
replication and transcription. We previously reported several structural states of the …
replication and transcription. We previously reported several structural states of the …
RNA polymerase II transcription: structure and mechanism
X Liu, DA Bushnell, RD Kornberg - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
A minimal RNA polymerase II (pol II) transcription system comprises the polymerase and five
general transcription factors (GTFs) TFIIB,-D,-E,-F, and-H. The addition of Mediator enables …
general transcription factors (GTFs) TFIIB,-D,-E,-F, and-H. The addition of Mediator enables …
[HTML][HTML] Nidovirus RNA polymerases: complex enzymes handling exceptional RNA genomes
CC Posthuma, AJW Te Velthuis, EJ Snijder - Virus research, 2017 - Elsevier
Coronaviruses and arteriviruses are distantly related human and animal pathogens that
belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus …
belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus …
Human DNA polymerase θ grasps the primer terminus to mediate DNA repair
DNA polymerase θ protects against genomic instability via an alternative end-joining repair
pathway for DNA double-strand breaks. Polymerase θ is overexpressed in breast, lung and …
pathway for DNA double-strand breaks. Polymerase θ is overexpressed in breast, lung and …
Dengue virus non-structural protein 5
A El Sahili, J Lescar - Viruses, 2017 - mdpi.com
The World Health Organization estimates that the yearly number of dengue cases averages
390 million. This mosquito-borne virus disease is endemic in over 100 countries and will …
390 million. This mosquito-borne virus disease is endemic in over 100 countries and will …