Alcohol and the liver

A Reuben - Current opinion in gastroenterology, 2008 - journals.lww.com
Alcohol and the liver : Current Opinion in Gastroenterology Alcohol and the liver : Current
Opinion in Gastroenterology Log in or Register Subscribe to journalSubscribe Get new issue …

Metabolic activation of 2-methylfuran to acetylacrolein and its reactivity toward cellular proteins

V Schäfer, S Stegmüller, H Becker… - Chemical Research in …, 2024 - ACS Publications
2-Methylfuran (2-MF) is a process-related contaminant found primarily in heat-treated foods,
such as coffee or canned food. The oxidative metabolic activation of 2-MF is supposed to …

Present status and perspective of pharmacogenetics in Mexico

P Cuautle-Rodríguez, A Llerena… - Drug metabolism and …, 2014 - degruyter.com
Drug costs account for up to 24% of the country's health expenditure and there are 13,000
registered drugs being prescribed. Diabetes is the main cause of death in the country, with …

Cytochrome P450 2E1 and head and neck cancer: interaction with genetic and environmental risk factors

M Ruwali, AJ Khan, PP Shah, AP Singh… - Environmental and …, 2009 - Wiley Online Library
The present case‐control study investigates the association of polymorphisms in cytochrome
P450 2E1 (CYP2E1), involved in the metabolism of tobacco carcinogens and alcohol, with …

The interaction of reward genes with environmental factors in contribution to alcoholism in Mexican Americans

Y Du, YJY Wan - Alcoholism: Clinical and Experimental …, 2009 - Wiley Online Library
Background: Alcoholism is a polygenic disorder resulting from reward deficiency;
polymorphisms in reward genes including serotonin transporter (5‐HTT)‐linked polymorphic …

Polymorphisms of Alcohol Metabolizing Enzymes in Indigenous Mexican Population: Unusual High Frequency of CYP2E1*c2 Allele

E Gordillo‐Bastidas, A Panduro… - Alcoholism: Clinical …, 2010 - Wiley Online Library
Background: Alcohol abuse represents the major identified etiological factor of cirrhosis in
México. ADH1B, ALDH2, and CYP2E1 have been considered candidate genes in alcohol …

Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis

AJ Khan, M Ruwali, G Choudhuri, N Mathur… - Mutation Research …, 2009 - Elsevier
The association of polymorphism in cytochrome P450 2E1 (CYP2E1), the major microsomal
ethanol metabolizing enzyme and its interaction with genes, involved in detoxification of …

Polymorphisms in drug‐metabolizing enzymes and risk to head and neck cancer: Evidence for gene–gene and gene–environment interaction

SS Maurya, G Anand, A Dhawan… - Environmental and …, 2014 - Wiley Online Library
A case–control study involving 750 cases with squamous‐cell carcinoma of the head and
neck (HNSCC) and an equal number of healthy controls was initiated to investigate the …

Cytochrome P450 2E1 gene polymorphisms/haplotypes and Parkinson's disease in a Swedish population

H Niazi Shahabi, L Westberg, J Melke… - Journal of neural …, 2009 - Springer
Abstract Cytochrome P450 2E1 (CYP2E1), which inter alia is located in dopamine
containing neurons in the substantia nigra, has been hypothesized to be of importance for …

Racial variations in the incidence of severe alcohol withdrawal

GM Chan, RS Hoffman, JA Gold, PJ Whiteman… - Journal of Medical …, 2009 - Springer
The use of race as a risk assessment tool and pharmacologic target has garnered recent
attention and debate. It is currently unclear if a relationship between race and the …