Recent strategies for the treatment of cancer, other than just tumor cell killing have been
under intensive development, such as anti-angiogenic therapeutic approach. Angiogenesis …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Metastasis is responsible for most cancer-related deaths, but the current clinical treatments
are not effective. Recently, gold nanoparticles (AuNPs) were discovered to inhibit cancer cell …

Tumor blood vessel formation is a key process for tumor expansion. Tumor vessels are
abnormal and differ from normal vessels in architecture and components. Besides oxygen …

Class III β-tubulin (βIII-tubulin) is frequently overexpressed in human tumors and is
associated with resistance to microtubule-targeting agents, tumor aggressiveness, and poor …

Targeting the colchicine binding site on tubulin is a promising strategy to develop cancer
therapeutics. Herein, we describe our systematic structure–activity relationship studies of …

We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines
as tubulin polymerization inhibitors targeting the colchicine binding site with significantly …

Oxygen-and sulphur-based heterocycles form the core structure of many biologically active
molecules as well as US FDA-approved drugs. Moreover, they possess broad range of …

Microtubules are essential for the mitotic division of cells and have been an attractive target
for antitumour drugs due to the increased incidence of cancer and significant mitosis rate of …

A series of new 6-aryl-1-(3, 4, 5-trimethoxyphenyl)-1H-benzo [d] imidazoles as tubulin
polymerization inhibitors targeting the colchicine-binding site were designed to restrict …