It is well known that cardiovascular disease manifests differently in women and men. The
underlying causes of these differences during the aging lifespan are less well understood …

The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain
receptor that mediates non-genomic estrogen related signaling. After ligand activation …

Ischaemic heart disease (IHD) is a complex disorder and a leading cause of death and
morbidity in both men and women. Sex, however, affects several aspects of IHD, including …

This review takes into consideration the main mechanisms involved in cellular remodeling
following an ischemic injury, with special focus on the possible role played by non-genomic …

Anthracyclines are the cornerstone for many oncologic treatments, but their cardiotoxicity
has been recognized for several decades. Female subjects, especially before puberty and …

ABSTRACT Introduction: The Notch pathway is involved in determining cell fate during
development and postnatally in continuously renewing tissues, such as the endothelium, the …

Mitochondria are key organelles for the maintenance of myocardial tissue homeostasis,
playing a pivotal role in adenosine triphosphate (ATP) production, calcium signaling, redox …

Stress-induced cardiovascular diseases characterized by inflammation are among the
leading causes of morbidity and mortality in postmenopausal women worldwide. Estradiol …

Cardiovascular disease (CVD) is still the leading cause of illness and death in the Western
world. Cardiovascular aging is a progressive modification occurring in cardiac and vascular …

Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths
are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an …