Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Neuroprotection for ischemic stroke refers to strategies, applied singly or in combination, that
antagonize the injurious biochemical and molecular events that eventuate in irreversible …

Background and Purpose—Induced hypothermia is a promising neuroprotective therapy.
We studied the feasibility and safety of hypothermia and thrombolysis after acute ischemic …

Objectives: The aim of this study was to confirm the cardioprotective effects of hypothermia
using a combination of cold saline and endovascular cooling. Background: Hypothermia has …

Background Targeted temperature management (TTM) is often used in neurocritical care to
minimize secondary neurologic injury and improve outcomes. TTM encompasses …

Objective: To report results of a randomized pilot clinical feasibility trial of endovascular
cooling in patients with ischemic stroke. Methods: Forty patients with ischemic stroke …

Background—Experimental studies have shown that induction of hypothermia before
reperfusion of acute coronary occlusion reduces infarct size. Previous clinical studies …

Hypothermia is widely accepted as the gold-standard method by which the body can protect
the brain. Therapeutic cooling—or targeted temperature management (TTM)—is …

Core body temperature is normally tightly regulated by an effective thermoregulatory system.
Thermoregulatory control is sometimes impaired by serious illness, but more typically …

Materials and Methods: The present study was carried out on 80 patients, in American
Society of Anesthesiologists I and II, aged 22–59 years, who underwent general anesthesia …