In recent decades, several viruses have resulted in large outbreaks with serious health,
economic and social consequences. The current unprecedented outbreak of the new …

Hybridization is an important strategy to design molecules that can be effectively used to
treat fatal diseases known to mankind. Molecular hybrids and their pharmacological …

In this work, novel 5-fluoro-1-methyl/ethyl-1H-indole-2, 3-dione 3-[4-(substituted phenyl)-
thiosemicarbazones] 6a-n and 7a-n were synthesized. The antiviral effects of the …

Hepatocellular carcinoma (HCC) represents around 85% of all known types of liver cancers
and is estimated to be the fifth most common cause of cancer-related death worldwide. The …

Molecular hybridization has a wide application in medicinal chemistry to obtain new
biologically active compounds. New isatin-indole molecular hybrids 5a–n have been …

The synthesis and molecular characterization of new isatin-based hydrazonoindolin-2-ones
4a-o and 7a-e are reported. The in vitro anti-proliferative potential of the synthesized …

Aim: The main goal was to create two new groups of indole derivatives, hydrazine-1-
carbothioamide (4a and 4b) and oxadiazole (5, and 6a–e) that target EGFR (4a, 4b, 5) or …

A novel series of pyrazole‐oxindole conjugates were prepared and characterized as
potential cytotoxic agents by FT‐IR, NMR and HR‐MS. The cytotoxic activity of these …

Background: The isatin molecule is present in many natural substances, including plants
and animals, and is used to prepare compounds with various biological activities …

Protein kinazlar hücre büyümesi, farklılaşması ve çoğalmasını düzenleyen sinyal iletim
yolaklarındaki önemli rollerinden dolayı kanser tedavisinde kullanılan ilaçları geliştirmede …