Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way
for numerous studies on hormone signalling networks and actions in peripheral tissues and …

Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Tau microtubule-associated proteins, encoded by the MAPT gene, are mainly expressed in
neurons participating in axonal transport and synaptic plasticity. Six major isoforms …

Alzheimer's disease (AD) poses an ever-increasing public health concern as the population
ages, affecting more than 6 million Americans. AD patients present with mood and sleep …

Tau protein (MAPT) is classified as a microtubule-associated protein (MAP) and is believed
to regulate the axonal microtubule arrangement. It belongs to the tau/MAP2/MAP4 family of …

In the last two decades, the amyloid hypothesis, ie, the abnormal accumulation of toxic Aβ
assemblies in the brain, has been considered the mainstream concept sustaining research …

Tau is a microtubule-associated binding protein in the nervous system that is known for its
role in stabilizing microtubules throughout the nerve cell. It accumulates as β-sheet-rich …

Tau is a microtubule-associated protein (MAPT, tau) implicated in the pathogenesis of
tauopathies, a spectrum of neurodegenerative disorders characterized by accumulation of …