Dissecting the clinical heterogeneity of early-onset Alzheimer's disease

DW Sirkis, LW Bonham, TP Johnson, R La Joie… - Molecular …, 2022 - nature.com
Early-onset Alzheimer's disease (EOAD) is a rare but particularly devastating form of AD.
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …

Temporopolar regions of the human brain

MM Mesulam - Brain, 2023 - academic.oup.com
Following prolonged neglect during the formative decades of behavioural neurology, the
temporopolar region has become a site of vibrant research on the neurobiology of cognition …

Speech and language impairments in behavioral variant frontotemporal dementia: a systematic review

A Geraudie, P Battista, AM García, IE Allen… - Neuroscience & …, 2021 - Elsevier
Although behavioral variant frontotemporal dementia (bvFTD) is classically defined by
behavioral and socio-emotional changes, impairments often extend to other cognitive …

Understanding the multidimensional cognitive deficits of logopenic variant primary progressive aphasia

S Ramanan, M Irish, K Patterson, JB Rowe… - Brain, 2022 - academic.oup.com
The logopenic variant of primary progressive aphasia is characterized by early deficits in
language production and phonological short-term memory, attributed to left-lateralized …

Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia

MM Mesulam, CA Coventry, EH Bigio, J Sridhar, N Gill… - Brain, 2022 - academic.oup.com
Primary progressive aphasia is a neurodegenerative disease that selectively impairs
language without equivalent impairment of speech, memory or comportment. In 118 …

Primary progressive aphasia: six questions in search of an answer

CRS Belder, CR Marshall, J Jiang, S Mazzeo… - Journal of …, 2024 - Springer
Here, we review recent progress in the diagnosis and management of primary progressive
aphasia—the language-led dementias. We pose six key unanswered questions that …

Heterogeneity and overlap in the continuum of linguistic profile of logopenic and semantic variants of primary progressive aphasia: a Profile Analysis based on …

GC Santi, F Conca, V Esposito, C Polito… - Alzheimer's Research & …, 2024 - Springer
Background Primary progressive aphasia (PPA) diagnostic criteria underestimate the
complex presentation of semantic (sv) and logopenic (lv) variants, in which symptoms …

Frontotemporal dementia

DG Clark - CONTINUUM: Lifelong Learning in Neurology, 2024 - journals.lww.com
Frontotemporal Dementia : CONTINUUM: Lifelong Learning in Neurology Account Register
Activate Subscription Help Subscribe American Academy of Neurology Login Journal logo …

Genetic forms of primary progressive aphasia within the GENetic Frontotemporal dementia Initiative (GENFI) cohort: comparison with sporadic primary progressive …

K Samra, AM MacDougall, A Bouzigues… - Brain …, 2023 - academic.oup.com
Primary progressive aphasia is most commonly a sporadic disorder, but in some cases, it
can be genetic. This study aimed to understand the clinical, cognitive and imaging …

[HTML][HTML] Identifying and diagnosing TDP-43 neurodegenerative diseases in psychiatry

S Ducharme, Y Pijnenburg, JD Rohrer, E Huey… - The American Journal of …, 2024 - Elsevier
Neuropsychiatric symptoms (NPS) are common manifestations of neurodegenerative
disorders and are often early signs of those diseases. Among those neurodegenerative …