The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for
enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid …

Cytochrome P450s comprise a superfamily of heme-thiolate proteins named for the spectral
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …

Some cytochrome P450 (CYP) heme-thiolate enzymes participate in the detoxication and,
paradoxically, the formation of reactive intermediates of thousands of chemicals that can …

This study reviews current understanding of mechanisms of biotransformation of
organophosphorus compounds (OPC). The first part of this article covers chemical aspects …

This review updates and evaluates the currently available information regarding the
pharmacokinetics, metabolism and interactions of the acid pump inhibitors omeprazole …

The beautiful report by Sachse et al.(1997) in this issue of the Journal represents the
culmination of 2 decades of increasingly exciting work on the" debrisoquine oxidation …

Response to drugs can vary between individuals and between different ethnic populations.
The biological (age, gender, disease and genetics), cultural and environmental factors …

The article examines the role of cytochrome P450 hemoproteins in the bioactivation and
detoxication of xenobiotic substances. Cytochrome P450 includes the families CYP1, CYP2 …

We thank the following scientists for valuable discussions on the proposed development of
the CEBS knowledge base: C. Afshari on basic design characteristics, R. DeWoskin on …

So-called 'drug-metabolizing enzyme'(DME) genes have existed on this planet for more than
2.5 billion years and would be more appropriately named 'effector-metabolizing enzymes' …