Clinical importance of the cytochromes P450
DW Nebert, DW Russell - The Lancet, 2002 - thelancet.com
The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for
enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid …
enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid …
The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
PB Danielson - Current drug metabolism, 2002 - ingentaconnect.com
Cytochrome P450s comprise a superfamily of heme-thiolate proteins named for the spectral
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis
DW Nebert, TP Dalton - Nature Reviews Cancer, 2006 - nature.com
Some cytochrome P450 (CYP) heme-thiolate enzymes participate in the detoxication and,
paradoxically, the formation of reactive intermediates of thousands of chemicals that can …
paradoxically, the formation of reactive intermediates of thousands of chemicals that can …
Biotransformation of organophosphorus compounds
M Jokanović - Toxicology, 2001 - Elsevier
This study reviews current understanding of mechanisms of biotransformation of
organophosphorus compounds (OPC). The first part of this article covers chemical aspects …
organophosphorus compounds (OPC). The first part of this article covers chemical aspects …
Pharmacokinetics, metabolism and interactions of acid pump inhibitors: focus on omeprazole, lansoprazole and pantoprazole
T Andersson - Clinical pharmacokinetics, 1996 - Springer
This review updates and evaluates the currently available information regarding the
pharmacokinetics, metabolism and interactions of the acid pump inhibitors omeprazole …
pharmacokinetics, metabolism and interactions of the acid pump inhibitors omeprazole …
Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?
DW Nebert - American journal of human genetics, 1997 - ncbi.nlm.nih.gov
The beautiful report by Sachse et al.(1997) in this issue of the Journal represents the
culmination of 2 decades of increasingly exciting work on the" debrisoquine oxidation …
culmination of 2 decades of increasingly exciting work on the" debrisoquine oxidation …
Pharmacogenetics and psychopharmacotherapy
Poolsup, LW Po, Knight - Journal of clinical pharmacy and …, 2000 - Wiley Online Library
Response to drugs can vary between individuals and between different ethnic populations.
The biological (age, gender, disease and genetics), cultural and environmental factors …
The biological (age, gender, disease and genetics), cultural and environmental factors …
Concise review of the cytochrome P450s and their roles in toxicology.
CJ Omiecinski, RP Remmel… - Toxicological …, 1999 - search.ebscohost.com
The article examines the role of cytochrome P450 hemoproteins in the bioactivation and
detoxication of xenobiotic substances. Cytochrome P450 includes the families CYP1, CYP2 …
detoxication of xenobiotic substances. Cytochrome P450 includes the families CYP1, CYP2 …
[PDF][PDF] Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base
M Waters - Environmental Health Perspectives, 2003 - ehp.niehs.nih.gov
We thank the following scientists for valuable discussions on the proposed development of
the CEBS knowledge base: C. Afshari on basic design characteristics, R. DeWoskin on …
the CEBS knowledge base: C. Afshari on basic design characteristics, R. DeWoskin on …
The evolution of drug metabolism
DW Nebert, MZ Dieter - Pharmacology, 2000 - karger.com
So-called 'drug-metabolizing enzyme'(DME) genes have existed on this planet for more than
2.5 billion years and would be more appropriately named 'effector-metabolizing enzymes' …
2.5 billion years and would be more appropriately named 'effector-metabolizing enzymes' …