The heterotrimeric laminins are a defining component of all basement membranes and self-
assemble into a cell-associated network. The three short arms of the cross-shaped laminin …

X-ray diffraction patterns from crystals of biological macromolecules contain sufficient
information to define atomic structures, but atomic positions are inextricable without having …

Netrins are secreted proteins that regulate axon guidance and neuronal migration. Deleted
in colorectal cancer (DCC) is a well-established netrin-1 receptor mediating attractive …

Netrin-1 is a guidance cue that can trigger either attraction or repulsion effects on migrating
axons of neurons, depending on the repertoire of receptors available on the growth cone …

Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism
to allow these tumors to escape the pro-apoptotic activity of some of its main dependence …

Crystal structure analyses for biological macromolecules without known structural relatives
entail solving the crystallographic phase problem. Typical de novo phase evaluations …

The function of neural circuits depends on the precise connectivity between populations of
neurons. Increasing evidence indicates that disruptions in excitatory or inhibitory synapse …

Structure determinations for biological macromolecules that have no known structural
antecedents typically involve the incorporation of heavier atoms than those found natively in …

Branched networks are ubiquitous throughout nature, particularly found in tissues that
require large surface area within a restricted volume. Many tissues with a branched …

The heterotrimeric laminins are a defining component of basement membranes and
essential for tissue formation and function in all animals. The three short arms of the cross …