Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …

Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial
outer membrane permeabilization. However, the mechanism by which they assemble the …

Through their many and varied metabolic functions, mitochondria power life. Paradoxically,
mitochondria also have a central role in apoptotic cell death. Upon induction of …

Many new types of regulated cell death have been recently implicated in human health and
disease. These regulated cell deaths have different morphological, genetic, biochemical …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …