Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Having made substantial progress understanding molecules, cells, genes and pathways,
aging biology research is now moving toward integration of these parts, attempting to …

Senescent cells accumulate with aging and at etiological sites of multiple diseases,
including those accounting for most morbidity, mortality, and health costs. Senescent cells …

Aging is a pleiotropic process affecting many aspects of mammalian physiology. Mammals
are composed of distinct cell type identities and tissue environments, but the influence of …

William Osler, generally considered the Father of Modern Medicine, commented that
variability among individuals represented the main barrier to medical practice transitioning …

The global increase in the aging population is expected to result in a shift from disease-
centered to function-centered approaches in response to intensive aging. Thus, the World …

Resilience as one of the pillars of successful aging has received increasing attention from
the scientific community in recent years and has become even more important post-Covid …

Decline in biological resilience (ability to recover) is a key manifestation of aging that
contributes to increase in vulnerability to death with age eventually limiting longevity even in …

Background Geriatricians are often confronted with unexpected health outcomes in older
adults with complex multimorbidity. Aging researchers have recently called for a focus on …

The traditional disease-oriented model of healthcare is inadequate to address the needs of
the older population. Greater attention should be given to strategies that promote healthy …