Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …

Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …

LVEF indicates left ventricular ejection fraction; CMR, cardiac magnetic resonance; LGE, late
gadolinium enhancement; TDI, tissue Doppler imaging; LVOTO, left ventricular outflow tract …

Over the last 2 decades, the pathogenic basis for the most common heritable cardiovascular
disease, hypertrophic cardiomyopathy (HCM), has been investigated extensively. Affecting …

Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and
defined by unexplained isolated progressive myocardial hypertrophy, systolic and diastolic …

Objective A predictable relation between genotype and disease expression is needed in
order to use genetic testing for clinical decision-making in hypertrophic cardiomyopathy …

The approach to molecular genetic studies of complex phenotypes evolved considerably
during the recent years. The candidate gene approach, which is restricted to an analysis of a …

Objectives: This study sought to assess the impact of body mass index (BMI) on cardiac
phenotypic and clinical course in a multicenter hypertrophic cardiomyopathy (HCM) cohort …

Eur J Clin Invest 2010; 40 (4): 360–369 Abstract Background Hypertrophic cardiomyopathy
(HCM) is the prototypic form of pathological cardiac hypertrophy. HCM is an important cause …

Rationale: A delicate balance between protein synthesis and degradation maintains cardiac
size and function. TRIM63 encoding Muscle RING Finger 1 (MuRF1) maintains muscle …