The continued evolution of biomedical nanotechnology has enabled clinicians to better
detect, prevent, manage, and treat human disease. In order to further push the limits of …

The structural complexity of glycans poses a serious challenge in the chemical synthesis of
glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by …

The quest for the construction of multivalent carbohydrate systems, with precise geometries
that are highly efficient in interacting with carbohydrate binding proteins, has been a goal of …

Nanoparticles with a diameter of< 100 nm are regarded as potential medical materials, as
this size allows nanoparticles to circulate in vivo and possibly reach targeted tumors …

Fluorescent nanodiamond (FND) is attracting much attention as a bioimaging agent
because of its inherent biocompatibility and superior optical properties (eg, excellent …

Abstract Development of targeted, selective, and noninvasive fluorescent probes for in vivo
visualization of tumor-associated overexpressed enzymes are highly anticipated for cancer …

A supramolecular carbohydrate-functionalized two-dimensional (2D) surface was designed
and synthesized by decorating thermally reduced graphene sheets with multivalent sugar …

Targeted delivery of therapeutic agents to hepatocytes is a particularly attractive strategy for
the treatment of hepatocellular carcinoma and other liver diseases. The asialoglycoprotein …

Hepatocellular carcinoma is a highly invasive malignant tumor of the liver, which is the main
cause of cancer-related death. The cancerization of hepatocytes may lead to the changes of …

A compact and stable bicyclic bridged ketal was developed as a ligand for the
asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency …