Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
Adaptive sequence divergence forged new neurodevelopmental enhancers in humans
Searches for the genetic underpinnings of uniquely human traits have focused on human-
specific divergence in conserved genomic regions, which reflects adaptive modifications of …
specific divergence in conserved genomic regions, which reflects adaptive modifications of …
Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7
H Zhang, Y Shao, Z Yao, L Liu, H Zhang… - Annals of the …, 2022 - ard.bmj.com
Objectives To investigate the role of mechanical stress in cartilage ageing and identify the
mechanistic association during osteoarthritis (OA) progression. Methods F-box and WD …
mechanistic association during osteoarthritis (OA) progression. Methods F-box and WD …
[HTML][HTML] Genetics of osteoarthritis
G Aubourg, SJ Rice, P Bruce-Wootton… - Osteoarthritis and …, 2022 - Elsevier
Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …
The genetic architecture and evolution of the human skeletal form
The human skeletal form underlies bipedalism, but the genetic basis of skeletal proportions
(SPs) is not well characterized. We applied deep-learning models to 31,221 x-rays from the …
(SPs) is not well characterized. We applied deep-learning models to 31,221 x-rays from the …
Magnetic polysaccharide mesenchymal stem cells exosomes delivery microcarriers for synergistic therapy of osteoarthritis
Osteoarthritis (OA) is a prevalent degenerative disease that afflicts more than 250 million
people worldwide, impairing their mobility and quality of life. However, conventional drug …
people worldwide, impairing their mobility and quality of life. However, conventional drug …
[HTML][HTML] Osteoarthritis year in review: genetics, genomics, epigenetics
Objective In this review, we have highlighted the advances over the past year in genetics,
genomics and epigenetics in the field of osteoarthritis (OA). Methods A literature search of …
genomics and epigenetics in the field of osteoarthritis (OA). Methods A literature search of …
Bioceramic scaffolds with antioxidative functions for ROS scavenging and osteochondral regeneration
Osteoarthritis (OA) is a degenerative disease that involves excess reactive oxygen species
(ROS) and osteochondral defects. Although multiple approaches have been developed for …
(ROS) and osteochondral defects. Although multiple approaches have been developed for …
Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology
Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …
significant health and social problems worldwide, its exact etiology is still unclear. With an …