Potassium channels play critical roles in many physiological processes, providing a
selective permeation route for K+ ions in and out of a cell, by employing a carefully designed …

Ions transiting biomembranes might pass readily from water through ion-specific membrane
proteins if these protein channels provide environments similar to the aqueous solution …

Potassium channels modulate various cellular functions through efficient and selective
conduction of K+ ions. The mechanism of ion conduction in potassium channels has recently …

Ion selectivity of the potassium channel is crucial for regulating electrical activity in living
cells; however, the mechanism underlying the potassium channel selectivity that favors large …

Voltage-gated K+ (Kv) channels mediate the flow of K+ across the cell membrane by
regulating the conductive state of their activation gate (AG). Several Kv channels display …

The human ether-á-go-go–related gene (hERG1) channel conducts small outward K+
currents that are critical for cardiomyocyte membrane repolarization. The gain-of-function …

Heavy metal stress (HMS) is one of the most destructive abiotic stresses which seriously
affects the growth and development of plants. Recent studies have shown significant …

K+ channels allow selective permeation of K+, but not physiologically abundant Na+, at
almost diffusion limit rates. The conduction mechanism of K+ channels is still controversial …

We introduce a statistical and linear response theory of selective conduction in biological ion
channels with multiple binding sites and possible point mutation. We derive an effective …

G protein-gated inwardly rectifying potassium channels (GIRK) are essential for the
regulation of cellular excitability, a physiological function that relies critically on the …