[HTML][HTML] Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors

N Moussa, N Dayoub - Saudi Pharmaceutical Journal, 2023 - Elsevier
This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the
pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal …

Selective COX-2 inhibitors as anticancer agents: a patent review (2018-2023)

M Mahboubi-Rabbani, AH Abdolghaffari… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction COX-2 is a crucial enzyme in the manufacture of prostaglandins. The enzyme's
metabolites might have an important function as regulators of the inflammatory response …

Ligand based pharmacophore modelling and integrated computational approaches in the quest for small molecule inhibitors against hCA IX

V Saravanan, BK Chagaleti, SD Packiapalavesam… - RSC …, 2024 - pubs.rsc.org
Carbonic anhydrase IX is an important biomarker to fight hypoxic tumours in both initial and
metastatic stages of many forms of cancer. Overexpression of hCA IX in the hypoxic …

Identification of novel curcumin derivatives against pancreatic cancer: a comprehensive approach integrating 3D-QSAR pharmacophore modeling, virtual screening …

N Chahbaoui, S Khamouli, M Alaqarbeh… - Journal of …, 2023 - Taylor & Francis
Pancreatic cancer, known as the “silent killer,” poses a daunting challenge in cancer
therapy. The dysregulation of the PI3Kα signaling pathway in pancreatic cancer has …

Discovery of new Cdc2-like kinase 4 (CLK4) inhibitors via pharmacophore exploration combined with flexible docking-based ligand/receptor contact fingerprints and …

MF Al-Tawil, S Daoud, MH Ma'mon, MO Taha - RSC advances, 2022 - pubs.rsc.org
Cdc2-like kinase 4 (CLK4) inhibitors are of potential therapeutic value in many diseases
particularly cancer. In this study, we combined extensive ligand-based pharmacophore …

Identification of novel dual acting ligands targeting the adenosine A2A and serotonin 5-HT1A receptors

I Touati, M Abdalla, Y Boulaamane… - Journal of …, 2023 - Taylor & Francis
GPCRs are a family of transmembrane receptors that are profoundly linked to various
neurological disorders, among which is Parkinson's disease (PD). PD is the second most …

[HTML][HTML] Analgesic and Anti-inflammatory Activities of Trayodashang Guggulu, an Ayurvedic Formulation

S Gupta, YN Dey, P Kannojia, AK Halder, D Sharma… - Phytomedicine Plus, 2022 - Elsevier
Background: Trayodashang guggulu (TG) is a compound Ayurvedic formulation used in
Indian traditional system of medicine for the treatment of various inflammatory conditions like …

Computer-aided designing peptide inhibitors of human hematopoietic prostaglandin D2 synthase combined molecular docking and molecular dynamics simulation

J Cui, Y Feng, T Yang, X Wang, H Tang - Molecules, 2023 - mdpi.com
Human hematopoietic prostaglandin D2 synthase (HPGDS) is involved in the production of
prostaglandin D2, which participates in various physiological processes, including …

Molecular Docking Discovered Potential of Cyclooxygenase-2 Inhibitor Activity of Oily Compounds of Walnuts.

S Sundari, A Mas' ud, DRT Sari - Tropical Journal of Natural …, 2022 - search.ebscohost.com
Walnut is a nutritional dietary food containing omega-3 and omega-6 that benefits for the
human body. Walnut extract encourages biological properties, including lowering …

A comprehensive survey of drug-target interaction analysis in allopathy and siddha medicine

E Uma, T Mala, AV Geetha, D Priyanka - Artificial Intelligence in Medicine, 2024 - Elsevier
Effective drug delivery is the cornerstone of modern healthcare, ensuring therapeutic
compounds reach their intended targets efficiently. This paper explores the potential of …