[HTML][HTML] Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors
N Moussa, N Dayoub - Saudi Pharmaceutical Journal, 2023 - Elsevier
This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the
pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal …
pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal …
Selective COX-2 inhibitors as anticancer agents: a patent review (2018-2023)
M Mahboubi-Rabbani, AH Abdolghaffari… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction COX-2 is a crucial enzyme in the manufacture of prostaglandins. The enzyme's
metabolites might have an important function as regulators of the inflammatory response …
metabolites might have an important function as regulators of the inflammatory response …
Ligand based pharmacophore modelling and integrated computational approaches in the quest for small molecule inhibitors against hCA IX
V Saravanan, BK Chagaleti, SD Packiapalavesam… - RSC …, 2024 - pubs.rsc.org
Carbonic anhydrase IX is an important biomarker to fight hypoxic tumours in both initial and
metastatic stages of many forms of cancer. Overexpression of hCA IX in the hypoxic …
metastatic stages of many forms of cancer. Overexpression of hCA IX in the hypoxic …
Identification of novel curcumin derivatives against pancreatic cancer: a comprehensive approach integrating 3D-QSAR pharmacophore modeling, virtual screening …
Pancreatic cancer, known as the “silent killer,” poses a daunting challenge in cancer
therapy. The dysregulation of the PI3Kα signaling pathway in pancreatic cancer has …
therapy. The dysregulation of the PI3Kα signaling pathway in pancreatic cancer has …
Discovery of new Cdc2-like kinase 4 (CLK4) inhibitors via pharmacophore exploration combined with flexible docking-based ligand/receptor contact fingerprints and …
Cdc2-like kinase 4 (CLK4) inhibitors are of potential therapeutic value in many diseases
particularly cancer. In this study, we combined extensive ligand-based pharmacophore …
particularly cancer. In this study, we combined extensive ligand-based pharmacophore …
Identification of novel dual acting ligands targeting the adenosine A2A and serotonin 5-HT1A receptors
I Touati, M Abdalla, Y Boulaamane… - Journal of …, 2023 - Taylor & Francis
GPCRs are a family of transmembrane receptors that are profoundly linked to various
neurological disorders, among which is Parkinson's disease (PD). PD is the second most …
neurological disorders, among which is Parkinson's disease (PD). PD is the second most …
[HTML][HTML] Analgesic and Anti-inflammatory Activities of Trayodashang Guggulu, an Ayurvedic Formulation
Background: Trayodashang guggulu (TG) is a compound Ayurvedic formulation used in
Indian traditional system of medicine for the treatment of various inflammatory conditions like …
Indian traditional system of medicine for the treatment of various inflammatory conditions like …
Computer-aided designing peptide inhibitors of human hematopoietic prostaglandin D2 synthase combined molecular docking and molecular dynamics simulation
J Cui, Y Feng, T Yang, X Wang, H Tang - Molecules, 2023 - mdpi.com
Human hematopoietic prostaglandin D2 synthase (HPGDS) is involved in the production of
prostaglandin D2, which participates in various physiological processes, including …
prostaglandin D2, which participates in various physiological processes, including …
Molecular Docking Discovered Potential of Cyclooxygenase-2 Inhibitor Activity of Oily Compounds of Walnuts.
Walnut is a nutritional dietary food containing omega-3 and omega-6 that benefits for the
human body. Walnut extract encourages biological properties, including lowering …
human body. Walnut extract encourages biological properties, including lowering …
A comprehensive survey of drug-target interaction analysis in allopathy and siddha medicine
Effective drug delivery is the cornerstone of modern healthcare, ensuring therapeutic
compounds reach their intended targets efficiently. This paper explores the potential of …
compounds reach their intended targets efficiently. This paper explores the potential of …