Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer
protection against oxidant stress. The development of hypertension, muscle/neuro‑​ …

Natural antioxidants have received tremendous attention over the last 3 decades. At the
same time, the attitude to free radicals is slowly changing, and their signalling role in …

Morphine exhibits important pharmacological effects for which it has been used in medical
practice for quite a long time. However, it has a high addictive potential and can be abused …

Liver fibrosis is a significant health problem that can cause serious illness and death.
Unfortunately, a standard treatment for liver fibrosis has not been approved yet due to its …

Results: It was found that ammonia inhibited mitochondrial dehydrogenases activity caused
collapse of mitochondrial membrane potential (MMP), induced mitochondrial swelling …

Ammonia-induced mitochondrial dysfunction and energy crisis is known as a critical
consequence of hepatic encephalopathy (HE). Hence, mitochondria are potential targets of …

Hyperammonemia is associated with chronic and acute liver injury. There is no promising
therapeutic agent against ammonia-induced complications. Hence, finding therapeutic …

Manganese (Mn) is a trace element involved in many physiological processes. However,
excessive Mn exposure leads to neurological complications. Although no precise …

Vascular endothelial cell damage is related to many vascular diseases, including
cardiovascular disease (CVD). Reactive oxygen species (ROS) play a vital role in the …

In this study, the possible role of oxidative stress and nitric oxide (NO) synthase isoforms in
the development of morphine tolerance and dependence, and effect of alpha-lipoic acid on …