CD146, a multi-functional molecule beyond adhesion

Z Wang, X Yan - Cancer letters, 2013 - Elsevier
CD146 is a cell adhesion molecule (CAM) that is primarily expressed at the intercellular
junction of endothelial cells. CD146 was originally identified as a tumor marker for …

The endothelial tip-stalk cell selection and shuffling during angiogenesis

W Chen, P Xia, H Wang, J Tu, X Liang… - Journal of cell …, 2019 - Springer
Angiogenesis is a critical, fine-tuned, multi-staged biological process. Tip-stalk cell selection
and shuffling are the building blocks of sprouting angiogenesis. Accumulated evidences …

CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis

T Jiang, J Zhuang, H Duan, Y Luo… - Blood, The Journal …, 2012 - ashpublications.org
CD146 is a novel endothelial biomarker and plays an essential role in angiogenesis;
however, its role in the molecular mechanism underlying angiogenesis remains poorly …

MicroRNA 329 suppresses angiogenesis by targeting CD146

P Wang, Y Luo, H Duan, S Xing, J Zhang… - … and cellular biology, 2013 - Am Soc Microbiol
CD146, an endothelial biomarker, has been shown to be aberrantly upregulated during
pathological angiogenesis and functions as a coreceptor for vascular endothelial growth …

CD146 (cluster of differentiation 146) an adhesion molecule involved in vessel homeostasis

AS Leroyer, MG Blin, R Bachelier, N Bardin… - … , and vascular biology, 2019 - Am Heart Assoc
CD146 (cluster of differentiation 146) is an adhesion molecule that is expressed by different
cells constituting vessels, particularly endothelial cells. The last 30 years of research in this …

Role of CD146 (MCAM) in physiological and pathological angiogenesis—contribution of new antibodies for therapy

A Joshkon, X Heim, C Dubrou, R Bachelier… - Biomedicines, 2020 - mdpi.com
The fundamental role of cell adhesion molecules in mediating various biological processes
as angiogenesis has been well-documented. CD146, an adhesion molecule of the …

Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension

Z Ye, C Zhang, T Tu, M Sun, D Liu, D Lu, J Feng… - Nature …, 2013 - nature.com
Dysregulation of Wnt signalling leads to developmental defects and diseases. Non-
canonical Wnt signalling via planar cell polarity proteins regulates cell migration and …

Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice

Q Zeng, Z Wu, H Duan, X Jiang, T Tu, D Lu, Y Luo… - Protein & …, 2014 - academic.oup.com
CD146 is a newly identified endothelial biomarker that has been implicated in angiogenesis.
Though in vitro angiogenic function of CD146 has been extensively reported, in vivo …

CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis

H Yan, C Zhang, Z Wang, T Tu, H Duan, Y Luo… - Scientific reports, 2017 - nature.com
VEGF-C is essential for lymphangiogenesis during development and tumor progression.
VEGFR-3 is the well-known cognate receptor of VEGF-C to regulate lymphatic migration and …

Comparative characterization of mesenchymal stromal cells from multiple abdominal adipose tissues and enrichment of angiogenic ability via CD146 molecule

NE Lee, SJ Kim, SJ Yang, SY Joo, H Park, KW Lee… - Cytotherapy, 2017 - Elsevier
Background There are various types of adipose tissue in the human body, and their
morphology is known to be closely related to cell function and metabolism. However, the …