Leishmaniasis is a neglected infectious disease caused by several different species of
protozoan parasites of the genus Leishmania. Current strategies to control this disease are …

Leishmaniases remain a major public health problem today despite the vast amount of
research conducted on Leishmania pathogens. The biological model is genetically and …

Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Gene expression in Kinetoplastids is very unusual in that the open reading frames are
arranged in long polycistronic arrays, monocistronic mRNAs being created by post …

Leishmania amastigotes primarily proliferate within macrophages in the mammalian host.
Genome-based metabolic reconstructions, combined with biochemical, reverse genetic and …

Leishmania are protozoan parasites that cause a wide spectrum of clinical diseases in
humans and are a major public health risk in several countries. Leishmania life cycle …

While gene expression is a fundamental and tightly controlled cellular process that is
regulated at multiple steps, the exact contribution of each step remains unknown in any …

Kinetoplastids branched early from the eukaryotic lineage and include several parasitic
protozoan species. Up to several hundred kinetoplastid genes are co-transcribed into …

Abstract The Leishmania tarentolae Parrot-TarII strain genome sequence was resolved to an
average 16-fold mean coverage by next-generation DNA sequencing technologies. This is …

Leishmania occurs in several developmental forms and thus undergoes complex cell
differentiation events during its life-cycle. Those are required to allow the parasite to adapt to …