Abstract Type 2 diabetes (T2D) mellitus has emerged as a major global health concern that
has accelerated in recent years due to poor diet and lifestyle. Afflicted individuals have high …

For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Islet transplantation is a promising treatment for type 1 diabetes (T1D), yet the low donor
pool, poor islet engraftment, and life-long immunosuppression prevent it from becoming the …

Organogenesis is a complex process that relies on a dynamic interplay between extrinsic
factors originating from the microenvironment and tissue-specific intrinsic factors. For …

Tremendous progress has been made over the last two decades in the field of pancreatic
beta cell replacement therapy as a curative measure for diabetes. Transplantation studies …

In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as
diabetes treatment. Despite recent progress, efforts to generate physiologically competent β …

The interplay between pancreatic epithelium and the surrounding microenvironment is
pivotal for pancreas formation and differentiation as well as adult organ homeostasis. The …

Hyperglycaemia causes pancreatic β-cells to release insulin that then attaches to a specific
expression of receptor isoform and reverses high glucose concentrations. It is well known …

The ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key
aspect of postnatal beta cell function. However, terminally differentiated beta cell identity …

Generating comprehensive image maps, while preserving spatial three-dimensional (3D)
context, is essential in order to locate and assess quantitatively specific cellular features and …