The burden of disease and death attributable to environmental pollution is becoming a
public health challenge worldwide, especially in developing countries. The kidney is …

Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …

Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated
with urothelial carcinoma of the upper urinary tract (UUC). Following metabolic activation …

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and shows
a propensity to metastasize and infiltrate adjacent and more distant tissues. HCC is …

The term “aristolochic acid nephropathy”(AAN) is used to include any form of toxic interstitial
nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) as …

Aristolochic acid (AA), a natural product of Aristolochia plants found in herbal remedies and
health supplements, is a group 1 carcinogen that can cause nephrotoxicity and upper …

Alterations in genome sequence and structure contribute to somatic disease, affect the
fitness of subsequent generations and drive evolutionary processes. The crucial roles of …

Aristolochic acids (AAs) are a group of toxins commonly present in the plants of genus
Aristolochia and Asarum, which are spread all over the world. Since the 1990s, AA-induced …

Current non-invasive approaches for detection of urothelial cancers are suboptimal. We
developed a test to detect urothelial neoplasms using DNA recovered from cells shed into …

In humans, exposure to aristolochic acid (AA) is associated with urothelial carcinoma of the
upper urinary tract (UTUC). Exome sequencing of UTUCs from 19 individuals with …