Paclitaxel (PTX), the most widely used anticancer drug, is applied for the treatment of
various types of malignant diseases. Mechanisms of PTX action represent several ways in …

Mitosis-specific agents have, to date, not been clinically successful. By contrast, microtubule-
targeting agents (MTAs) have a long record of success, usually attributed to the induction of …

The patient population suffering from pancreatic ductal adenocarcinoma (PDAC) presents,
as a whole, with a high degree of molecular tumor heterogeneity. The heterogeneity of …

Paclitaxel (PTX) is a chemotherapeutical agent commonly used to treat several kinds of
cancer. PTX is known as a microtubule-targeting agent with a primary molecular mechanism …

ABSTRACT Three-dimensional (3D) cell motility underlies essential processes, such as
embryonic development, tissue repair and immune surveillance, and is involved in cancer …

Voltage-gated sodium channels (VGSCs), which are abnormally expressed in various types
of cancers such as breast cancer, prostate cancer, lung cancer, and cervical cancer, are …

Background Breast cancer remains a leading cause of death in women and novel imaging
biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment …

Microtubules regulate signaling, trafficking, and cell mechanics, but the respective
contribution of these functions to cell morphogenesis and migration in 3D matrices is …

Tremendous data have been accumulated in the effort to understand chemoresistance of
triple negative breast cancer (TNBC). However, modifications in cancer cells surviving …

Anticancer drugs directed against the microtubule, including taxanes and vinca alkaloids,
have been the backbone of many chemotherapy regimes for decades. These drugs have …