Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair

N Rahmanian, M Shokrzadeh, M Eskandani - DNA repair, 2021 - Elsevier
The phosphorylation of histone variant H2AX and formation of γH2AX is a primary response
to the DNA double-strand breaks (DSBs). Detection of γH2AX is a robust and sensitive tool …

[HTML][HTML] KIF2C: An important factor involved in signaling pathways, immune infiltration, and DNA damage repair in tumorigenesis

RQ Li, Y Yang, L Qiao, L Yang, DD Shen… - Biomedicine & …, 2024 - Elsevier
Backgrounds Poorly regulated mitosis and chromosomal instability are common
characteristics in malignant tumor cells. Kinesin family member 2 C (KIF2C), also known as …

KIF2C is a novel prognostic biomarker and correlated with immune infiltration in endometrial cancer

L An, J Zhang, D Feng, Y Zhao, W Ouyang… - Stem cells …, 2021 - Wiley Online Library
Endometrial cancer (EC) is commonly diagnosed cancer in women, and the prognosis of
advanced types of EC is extremely poor. Kinesin family member 2C (KIF2C) has been …

Large-scale transcriptome data analysis identifies KIF2C as a potential therapeutic target associated with immune infiltration in prostate cancer

P Zhang, H Gao, C Ye, R Yan, L Yu, C Xia… - Frontiers in …, 2022 - frontiersin.org
Prostate cancer (PCa) is one of the most prevalent cancers of the urinary system. In previous
research, Kinesin family member 2C (KIF2C), as an oncogene, has been demonstrated to …

KIF2C/MCAK a prognostic biomarker and its oncogenic potential in malignant progression, and prognosis of cancer patients: a systematic review and meta-analysis …

NN Kreis, HH Moon, L Wordeman… - Critical Reviews in …, 2024 - Taylor & Francis
Abstract KIF2C/MCAK (KIF2C) is the most well-characterized member of the kinesin-13
family, which is critical in the regulation of microtubule (MT) dynamics during mitosis, as well …

In Silico Analysis of the correlation of KIF2C with prognosis and Immune Infiltration in Glioma

B Tu, H Xiang, M Li, F Zhong, M Fang… - … Methods in Medicine, 2022 - Wiley Online Library
Glioblastoma (GBM) is one of the most commonly pivotal malignant caners. Numerous
reports have revealed the crucial roles of immune infiltration in the initiation and progression …

[HTML][HTML] An in-silico approach leads to explore six genes as a molecular signatures of lung adenocarcinoma

MA Abdel-Maksoud, F Hassan, U Mubarik… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Due to heterogenetic-specific nature of the available biomarkers, the incidence of lung
adenocarcinoma (LUAD) is on the rise worldwide. Previously reported LUAD-related hub …

Production of CRISPR‐Cas9 Transgenic Cell Lines for Knocksideways Studies

M Wagenbach, JJ Vicente, W Wagenbach… - Current …, 2023 - Wiley Online Library
Protein activity is generally functionally integrated and spatially restricted to key locations
within the cell. Knocksideways experiments allow researchers to rapidly move proteins to …

Activation of the TGF-β1/Smad signaling by KIF2C contributes to the malignant phenotype of thyroid carcinoma cells

Q Lin, Q Qi, S Hou, Z Chen, N Jiang, L Zhang, C Lin - Tissue and Cell, 2021 - Elsevier
Kinesin family member 2C (KIF2C) has been identified as a potential oncogene in various
types of human cancers; however, the role of KIF2C in thyroid cancer has not yet been …

Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer

S Li, Y Ma, C Wu, X Hou - 2023 - digitum.um.es
Kinesin family member 2C (KIF2C) was reported to act as a vital player in several human
cancers. However, the exact function of KIF2C in gastric cancer (GC) is poorly understood. In …