Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic is hypothesized to be driven by an overreacting innate immune response, where …

The humoral arm of innate immunity includes diverse molecules with antibody-like functions,
some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID …

The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …

Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

The complement system is an important part of the innate immune defence. It contributes not
only to local inflammation, removal and killing of pathogens, but it also assists in shaping of …

The increasing number of clinical conditions that involve a pathological contribution from the
complement system—many of which affect the kidneys—has spurred a regained interest in …

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …