Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that
comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients …

The peripheral nervous system controls the functions of sensation, movement and motor
coordination of the body. Peripheral nerves can get damaged easily by trauma or …

Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome caused by NF1
gene mutation, in which affected patients develop Schwann cell lineage peripheral nerve …

Plexiform neurofibromas (pNFs) are developmental tumors that appear in neurofibromatosis
type 1 individuals, constituting a major source of morbidity and potentially transforming into a …

Schwann cells are glial cells of the peripheral nervous system. They exist in several
subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are …

Abstract Purpose of Review Patients with neurofibromatosis type 1 (NF1) are at increased
risk for benign and malignant neoplasms. Recently, targeted therapy with the MEK inhibitor …

Schwann cells (SCs) have a critical role in the peripheral nervous system. These cells are
able to support axons during homeostasis and after injury. However, mutations in genes …

Cancer research has considerably progressed with the improvement of in vitro study
models, helping to understand the key role of the tumor microenvironment in cancer …

Background Plexiform neurofibromas can transform into atypical neurofibromas (ANF) and
then further progress to aggressive malignant peripheral nerve sheath tumors (MPNST) …

Neurofibromatosis Type 1 (NF1) is a common genetic disorder and cancer predisposition
syndrome (1: 3000 births) caused by mutations in the tumor suppressor gene NF1. NF1 …