Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

Rationale: Clonal hematopoiesis driven by mutations of DNMT3A (DNA methyltransferase
3a) is associated with increased incidence of cardiovascular disease and poor prognosis of …

Therapeutic T cells with desired specificity can be engineered by introducing T-cell
receptors (TCRs) specific for antigens of interest, such as those from pathogens or tumour …

T cells are critical in orchestrating protective immune responses to cancer and an array of
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …

Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin
lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of …

Granulomas are organized aggregates of macrophages, often with characteristic
morphological changes, and other immune cells. These evolutionarily ancient structures …

Resistance to checkpoint-blockade treatments is a challenge in the clinic. We found that
although treatment with combined anti-CTLA-4 and anti-PD-1 improved control of …

Abstract Peptide-MHC (pMHC) multimers, usually used as streptavidin-based tetramers,
have transformed the study of Ag-specific T cells by allowing direct detection, phenotyping …

Innate immune responses that control early Mtb infection are poorly understood, but
understanding these responses may inform vaccination and immunotherapy strategies …