Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a
significant assembly motif for the development of new drug entities. Quinoline and its …

Quinoline and its fused heterocyclic derivatives tested with diverse pharmacological activity
constitute an important class of compounds for new drug development. Therefore, many …

Malaria is a major public health problem mainly due to the development of resistance by the
most lethal causative parasitic species, Plasmodium falciparum to the mainstay drugs like …

Recent Progress in the Synthesis of Quinolines Page 1 Current Organic Chemistry, 2005, 9,
141-161 141 1385-2728/05 $50.00+.00 © 2005 Bentham Science Publishers Ltd. Recent …

Approximately 40% of the world population live in areas with the risk of malaria. Each year,
300–500 million people suffer from acute malaria, and 0.5–2.5 million die from the disease …

Quinoline is one of the most widely investigated scaffolds by synthetic chemists because of
its medicinal importance. A wide range of metal-catalyzed, metal-free, multi-step or domino …

Formation of malaria pigment or haemozoin is the major route of haem detoxification in the
malaria parasite Plasmodium falciparum as well as several other species of …

In this work we report spectroscopic characterization and reactivity study by density
functional theory (DFT) and molecular dynamics (MD) simulations of two quinoline …

Model systems have been studied using density functional theory to assess the contributions
of π-resonance and through-space effects on electrostatic potentials (ESPs) of substituted …

Most antimalarials are based on basic N-heterocycles and possess amine functionalities.
Despite this, the role of basic nitrogen (BaN) in antimalarial drug design has not been …