When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance

CY Kuo, DK Ann - Cancer Communications, 2018 - Springer
The role of fatty acid metabolism, including both anabolic and catabolic reactions in cancer
has gained increasing attention in recent years. Many studies have shown that aberrant …

The effects of adipocytes on the regulation of breast cancer in the tumor microenvironment: an update

DT Chu, T Nguyen Thi Phuong, NLB Tien, DK Tran… - Cells, 2019 - mdpi.com
Obesity is a global pandemic and it is well evident that obesity is associated with the
development of many disorders including many cancer types. Breast cancer is one of that …

Metronomic and single high-dose paclitaxel treatments produce distinct heterogenous chemoresistant cancer cell populations

C Mejia Peña, TA Skipper, J Hsu, I Schechter… - Scientific Reports, 2023 - nature.com
More than 75% of epithelial ovarian cancer (EOC) patients experience disease recurrence
after initial treatment, highlighting our incomplete understanding of how chemoresistant …

Rediscovery of NF‐κB signaling in nasopharyngeal carcinoma: How genetic defects of NF‐κB pathway interplay with EBV in driving oncogenesis?

M Yi, J Cai, J Li, S Chen, Z Zeng, Q Peng… - Journal of cellular …, 2018 - Wiley Online Library
Nasopharyngeal carcinoma (NPC) is a unique EBV‐associated subtype of head and neck
cancer, which has the highest incidence in Southern China and eastern South Asia. The …

Cancer stem cells in ovarian cancer—a source of tumor success and a challenging target for novel therapies

JR Wilczyński, M Wilczyński, E Paradowska - International Journal of …, 2022 - mdpi.com
Ovarian cancer is the most lethal neoplasm of the female genital organs. Despite
indisputable progress in the treatment of ovarian cancer, the problems of chemo-resistance …

Linoleic and oleic acids enhance cell migration by altering the dynamics of microtubules and the remodeling of the actin cytoskeleton at the leading edge

M Masner, N Lujea, M Bisbal, C Acosta, P Kunda - Scientific reports, 2021 - nature.com
Fatty acids (FA) have a multitude of biological actions on living cells. A target of their action
is cell motility, a process of critical importance during cancer cell dissemination. Here, we …

A CD10‐OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1

S Yu, Y Lu, A Su, J Chen, J Li, B Zhou, X Liu… - Advanced …, 2021 - Wiley Online Library
Carcinoma‐associated fibroblasts (CAFs) consist of heterogeneous subpopulations that
play a critical role in the dynamics of the tumor microenvironment. The extracellular signals …

Insight into the role of multiple signaling pathways in regulating cancer stem cells of gynecologic cancers

Y Song, S Pan, K Li, X Chen, ZP Wang, X Zhu - Seminars in Cancer …, 2022 - Elsevier
Mounting evidence has demonstrated that a myriad of developmental signaling pathways,
such as the Wnt, Notch, Hedgehog and Hippo, are frequently deregulated and play a critical …

Challenges and opportunities in obesity: the role of adipocytes during tissue fibrosis

Q Zhang, C Lu, F Lu, Y Liao, J Cai, J Gao - Frontiers in Endocrinology, 2024 - frontiersin.org
Obesity is a chronic disease that affects the energy balance of the whole body. In addition to
increasing fat mass, tissue fibrosis occurred in white adipose tissue in obese condition …

[HTML][HTML] Y‑box binding protein 1 acts as a negative regulator of stearoyl CoA desaturase 1 in clear cell renal cell carcinoma

E Jeffords, S Freeman, B Cole, K Root… - Oncology …, 2020 - spandidos-publications.com
Y‑box binding protein 1 (YB‑1) is a regulatory protein associated with oncogenesis and poor
prognosis in patients with cancer. In the cell, YB‑1 functions as a DNA and RNA binding …