Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …
molecular underpinnings of this variability is of great relevance for developing individualized …
Epigenetics of stress-related psychiatric disorders and gene× environment interactions
A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …
disorders is important for the development of more efficient preventive and therapeutic …
The role of m6A/m-RNA methylation in stress response regulation
Summary N 6-methyladenosine (m 6 A) and N 6, 2′-O-dimethyladenosine (m 6 Am) are
abundant mRNA modifications that regulate transcript processing and translation. The role …
abundant mRNA modifications that regulate transcript processing and translation. The role …
[HTML][HTML] Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: a critical review
Early life stress (ELS) is a known risk factor for suffering psychopathology in adulthood. The
hypothalamic–pituitary–adrenal (HPA) axis has been described to be deregulated in both …
hypothalamic–pituitary–adrenal (HPA) axis has been described to be deregulated in both …
DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain
DNA methylation has become increasingly recognized in the etiology of psychiatric
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …
Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation
N Provençal, J Arloth, A Cattaneo… - Proceedings of the …, 2020 - National Acad Sciences
Prenatal stress exposure is associated with risk for psychiatric disorders later in life. This
may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known …
may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known …
Correspondence of DNA methylation between blood and brain tissue and its application to schizophrenia research
Given the difficulty of procuring human brain tissue, a key question in molecular psychiatry
concerns the extent to which epigenetic signatures measured in more accessible tissues …
concerns the extent to which epigenetic signatures measured in more accessible tissues …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential
M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …
Epigenetics of posttraumatic stress disorder: current evidence, challenges, and future directions
Posttraumatic stress disorder (PTSD) is a stress-related psychiatric disorder that is thought to
emerge from complex interactions among traumatic events and multiple genetic factors …
emerge from complex interactions among traumatic events and multiple genetic factors …