Advances in COVID-19 mRNA vaccine development

E Fang, X Liu, M Li, Z Zhang, L Song, B Zhu… - Signal transduction and …, 2022 - nature.com
To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …

Peptide-based vaccines for tuberculosis

W Gong, C Pan, P Cheng, J Wang, G Zhao… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …

An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study

Z Yang, P Bogdan, S Nazarian - Scientific reports, 2021 - nature.com
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over
the world has led to over millions of deaths, and devastated the social, financial and political …

A candidate multi-epitope vaccine against SARS-CoV-2

T Kar, U Narsaria, S Basak, D Deb, F Castiglione… - Scientific reports, 2020 - nature.com
In the past two decades, 7 coronaviruses have infected the human population, with two
major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012 …

In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases

RA Shey, SM Ghogomu, KK Esoh, ND Nebangwa… - Scientific reports, 2019 - nature.com
Onchocerciasis is a parasitic disease with high socio-economic burden particularly in sub-
Saharan Africa. The elimination plan for this disease has faced numerous challenges. A …

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

JM Rock, FF Hopkins, A Chavez, M Diallo… - Nature …, 2017 - nature.com
The development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis
has been limited by the complexity and time required for genetic manipulations in …

Contriving multi-epitope subunit of vaccine for COVID-19: immunoinformatics approaches

R Dong, Z Chu, F Yu, Y Zha - Frontiers in immunology, 2020 - frontiersin.org
COVID-19 has recently become the most serious threat to public health, and its prevalence
has been increasing at an alarming rate. The incubation period for the virus is~ 1–14 days …

Repurposing CRISPR-Cas12b for mammalian genome engineering

F Teng, T Cui, G Feng, L Guo, K Xu, Q Gao, T Li, J Li… - Cell discovery, 2018 - nature.com
The prokaryotic CRISPR-Cas adaptive immune systems provide valuable resources to
develop genome editing tools, such as CRISPR-Cas9 and CRISPR-Cas12a/Cpf1. Recently …

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

KM Esvelt, P Mali, JL Braff, M Moosburner, SJ Yaung… - Nature …, 2013 - nature.com
The Cas9 protein from the Streptococcus pyogenes CRISPR-Cas acquired immune system
has been adapted for both RNA-guided genome editing and gene regulation in a variety of …

Unifying the global phylogeny and environmental distribution of ammonia-oxidising archaea based on amoA genes

RJE Alves, BQ Minh, T Urich, A von Haeseler… - Nature …, 2018 - nature.com
Ammonia-oxidising archaea (AOA) are ubiquitous and abundant in nature and play a major
role in nitrogen cycling. AOA have been studied intensively based on the amoA gene …