Breast cancer is the most common cancer and the most frequent cause of cancer death
among women worldwide. Breast cancer is a complex, heterogeneous disease classified …

With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …

The conformational analysis of macrocycles is a complex and challenging problem. There
are many factors that contribute to this complexity. These include a large number of degrees …

Simple Summary Transcription factor NRF2 controls expression of antioxidant and
detoxification genes. Normally, the activity of NRF2 is tightly controlled in the cell, and is …

Heat shock protein 90 (Hsp90) is an evolutionary conserved molecular chaperone that,
together with Hsp70 and co-chaperones makes up the Hsp90 chaperone machinery …

The discovery and clinical development of heat shock protein 90 (Hsp90) inhibitors continue
to progress. A number of Hsp90 inhibitors are in clinical trials, and preclinical discoveries of …

Aging is now at the forefront of major challenges faced globally, creating an immediate need
for safe, widescale interventions to reduce the burden of chronic disease and extend human …

Covering: 2011 to 2021 The structural division of ansamycins, including those of atypical
cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid …

Simple Summary NRF2-activated or NRF2-addicted cancers show high incidence,
especially in esophageal squamous cell carcinoma (ESCC). ESCC with high NRF2 …