[HTML][HTML] The cell biology of systemic insulin function
VL Tokarz, PE MacDonald, A Klip - The Journal of cell biology, 2018 - ncbi.nlm.nih.gov
Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …
Network science of biological systems at different scales: A review
Network science is today established as a backbone for description of structure and function
of various physical, chemical, biological, technological, and social systems. Here we review …
of various physical, chemical, biological, technological, and social systems. Here we review …
Hepatic insulin clearance: mechanism and physiology
SM Najjar, G Perdomo - Physiology, 2019 - journals.physiology.org
Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …
Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity
J Wu, LJ Yan - Diabetes, metabolic syndrome and obesity: targets …, 2015 - Taylor & Francis
Chronic hyperglycemia and the corresponding glucotoxicity are the main pathogenic
mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal …
mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal …
Insulin clearance in health and disease
Insulin action is impaired in type 2 diabetes. The functions of the hormone are an integrated
product of insulin secretion from pancreatic β-cells and insulin clearance by receptor …
product of insulin secretion from pancreatic β-cells and insulin clearance by receptor …
cAMP signalling in insulin and glucagon secretion
A Tengholm, E Gylfe - Diabetes, obesity and metabolism, 2017 - Wiley Online Library
The “second messenger” archetype cAMP is one of the most important cellular signalling
molecules with central functions including the regulation of insulin and glucagon secretion …
molecules with central functions including the regulation of insulin and glucagon secretion …
Human beta cells produce and release serotonin to inhibit glucagon secretion from alpha cells
In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during
metabolic challenges such as those associated with pregnancy or high-fat diet. It is still …
metabolic challenges such as those associated with pregnancy or high-fat diet. It is still …
A causal role for hyperinsulinemia in obesity
Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and
lipogenesis at multiple levels. Elevated insulin levels are associated with obesity, and …
lipogenesis at multiple levels. Elevated insulin levels are associated with obesity, and …
Mechanisms and characteristics of sulfonylureas and glinides
W Lv, X Wang, Q Xu, W Lu - Current topics in medicinal …, 2020 - ingentaconnect.com
Background: Type 2 diabetes mellitus is a complex progressive endocrine disease
characterized by hyperglycemia and life-threatening complications. It is the most common …
characterized by hyperglycemia and life-threatening complications. It is the most common …
Unravelling innervation of pancreatic islets
RF Hampton, M Jimenez-Gonzalez, SA Stanley - Diabetologia, 2022 - Springer
The central and peripheral nervous systems play critical roles in regulating pancreatic islet
function and glucose metabolism. Over the last century, in vitro and in vivo studies along …
function and glucose metabolism. Over the last century, in vitro and in vivo studies along …