Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

In eukaryotes, chromatin and DNA replication are intimately linked, whereby chromatin
impacts DNA replication control while genome duplication involves recovery of chromatin …

Abstract Bromodomain Adjacent to Zinc Finger Domain 1A (BAZ1A) is a critical regulator of
chromatin remodeling. We sought to clarify the roles of BAZ1A in the etiology of colorectal …

Background The fatal diffuse midline gliomas (DMG) are characterized by an undruggable
H3K27M mutation in H3. 1 or H3. 3. K27M impairs normal development by stalling …

H3. 3 is a highly conserved nonreplicative histone variant. H3. 3 is enriched in promoters
and enhancers of active genes, but it is also found within suppressed heterochromatin …

Our understanding of cancer genomes has allowed for the integration of molecular data into
histopathological classifications for routine stratification of patients. In the last 10–15 years …

The mammalian genome, organised into chromatin, adopts a three-dimensional (3D) folding
within the cell nucleus with spatially segregated active and repressed compartments, termed …

The epigenome—the chemical modifications and chromatin-related packaging of the
genome—enables the same genetic template to be activated or repressed in different …

Atherosclerotic lesions develop preferentially in arterial regions exposed to disturbed blood
flow, where endothelial cells acquire an inflammatory phenotype. How disturbed flow …

Purpose Esophageal squamous cell carcinoma (ESCC) is a prevalent tumor in the
gastrointestinal tract, but our understanding of the molecular mechanisms underlying ESCC …