[HTML][HTML] WormBase ParaSite− a comprehensive resource for helminth genomics

KL Howe, BJ Bolt, M Shafie, P Kersey… - Molecular and …, 2017 - Elsevier
The number of publicly available parasitic worm genome sequences has increased
dramatically in the past three years, and research interest in helminth functional genomics is …

Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis

R Lalor, K Cwiklinski, NED Calvani, A Dorey, S Hamon… - Virulence, 2021 - Taylor & Francis
Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the
most important neglected parasitic diseases of humans and animals. The ability of the …

Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma

A Jusakul, I Cutcutache, CH Yong, JQ Lim, MN Huang… - Cancer discovery, 2017 - AACR
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in
countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries …

The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution

K Cwiklinski, JP Dalton, PJ Dufresne, J La Course… - Genome biology, 2015 - Springer
Abstract Background The liver fluke Fasciola hepatica is a major pathogen of livestock
worldwide, causing huge economic losses to agriculture, as well as 2.4 million human …

A prospective view of animal and human Fasciolosis

K Cwiklinski, SM O'neill, S Donnelly… - Parasite …, 2016 - Wiley Online Library
Fasciolosis, a food‐borne trematodiasis, results following infection with the parasites,
Fasciola hepatica and Fasciola gigantica. These trematodes greatly affect the global …

[HTML][HTML] Fasciola hepatica vaccine: we may not be there yet but we're on the right road

V Molina-Hernández, G Mulcahy, J Pérez… - Veterinary …, 2015 - Elsevier
Major advances have been made in identifying potential vaccine molecules for the control of
fasciolosis in livestock but we have yet to reach the level of efficacy required for …

Liver fluke-associated biliary tract cancer

P Prueksapanich, P Piyachaturawat… - Gut and …, 2017 - pmc.ncbi.nlm.nih.gov
Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile
duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In …

Carcinogenic liver fluke secretes extracellular vesicles that promote cholangiocytes to adopt a tumorigenic phenotype

S Chaiyadet, J Sotillo, M Smout… - The Journal of …, 2015 - academic.oup.com
Abstract Background. Throughout Asia, there is an unprecedented link between
cholangiocarcinoma and infection with the liver fluke Opisthorchis viverrini. Multiple …

A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance

NJ Beesley, K Cwiklinski, K Allen, RC Hoyle… - PLoS …, 2023 - journals.plos.org
Fasciola hepatica infection is responsible for substantial economic losses in livestock
worldwide and poses a threat to human health in endemic areas. The mainstay of control in …

Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human …

SN McNulty, JF Tort, G Rinaldi, K Fischer… - PLoS …, 2017 - journals.plos.org
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted
through the food chain, four of which are recognized as neglected tropical diseases (NTDs) …