[HTML][HTML] WormBase ParaSite− a comprehensive resource for helminth genomics
The number of publicly available parasitic worm genome sequences has increased
dramatically in the past three years, and research interest in helminth functional genomics is …
dramatically in the past three years, and research interest in helminth functional genomics is …
Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis
R Lalor, K Cwiklinski, NED Calvani, A Dorey, S Hamon… - Virulence, 2021 - Taylor & Francis
Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the
most important neglected parasitic diseases of humans and animals. The ability of the …
most important neglected parasitic diseases of humans and animals. The ability of the …
Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in
countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries …
countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries …
The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution
K Cwiklinski, JP Dalton, PJ Dufresne, J La Course… - Genome biology, 2015 - Springer
Abstract Background The liver fluke Fasciola hepatica is a major pathogen of livestock
worldwide, causing huge economic losses to agriculture, as well as 2.4 million human …
worldwide, causing huge economic losses to agriculture, as well as 2.4 million human …
A prospective view of animal and human Fasciolosis
K Cwiklinski, SM O'neill, S Donnelly… - Parasite …, 2016 - Wiley Online Library
Fasciolosis, a food‐borne trematodiasis, results following infection with the parasites,
Fasciola hepatica and Fasciola gigantica. These trematodes greatly affect the global …
Fasciola hepatica and Fasciola gigantica. These trematodes greatly affect the global …
[HTML][HTML] Fasciola hepatica vaccine: we may not be there yet but we're on the right road
V Molina-Hernández, G Mulcahy, J Pérez… - Veterinary …, 2015 - Elsevier
Major advances have been made in identifying potential vaccine molecules for the control of
fasciolosis in livestock but we have yet to reach the level of efficacy required for …
fasciolosis in livestock but we have yet to reach the level of efficacy required for …
Liver fluke-associated biliary tract cancer
P Prueksapanich, P Piyachaturawat… - Gut and …, 2017 - pmc.ncbi.nlm.nih.gov
Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile
duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In …
duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In …
Carcinogenic liver fluke secretes extracellular vesicles that promote cholangiocytes to adopt a tumorigenic phenotype
Abstract Background. Throughout Asia, there is an unprecedented link between
cholangiocarcinoma and infection with the liver fluke Opisthorchis viverrini. Multiple …
cholangiocarcinoma and infection with the liver fluke Opisthorchis viverrini. Multiple …
A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance
NJ Beesley, K Cwiklinski, K Allen, RC Hoyle… - PLoS …, 2023 - journals.plos.org
Fasciola hepatica infection is responsible for substantial economic losses in livestock
worldwide and poses a threat to human health in endemic areas. The mainstay of control in …
worldwide and poses a threat to human health in endemic areas. The mainstay of control in …
Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human …
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted
through the food chain, four of which are recognized as neglected tropical diseases (NTDs) …
through the food chain, four of which are recognized as neglected tropical diseases (NTDs) …