Exploring the human microbiome: the potential future role of next-generation sequencing in disease diagnosis and treatment

MA Malla, A Dubey, A Kumar, S Yadav… - Frontiers in …, 2019 - frontiersin.org
The interaction between the human microbiome and immune system has an effect on
several human metabolic functions and impacts our well-being. Additionally, the interaction …

The road to metagenomics: from microbiology to DNA sequencing technologies and bioinformatics

A Escobar-Zepeda, A Vera-Ponce de León… - Frontiers in …, 2015 - frontiersin.org
The study of microorganisms that pervade each and every part of this planet has
encountered many challenges through time such as the discovery of unknown organisms …

MetaBAT, an efficient tool for accurately reconstructing single genomes from complex microbial communities

DD Kang, J Froula, R Egan, Z Wang - PeerJ, 2015 - peerj.com
Grouping large genomic fragments assembled from shotgun metagenomic sequences to
deconvolute complex microbial communities, or metagenome binning, enables the study of …

A metagenome-wide association study of gut microbiota in type 2 diabetes

J Qin, Y Li, Z Cai, S Li, J Zhu, F Zhang, S Liang… - nature, 2012 - nature.com
Assessment and characterization of gut microbiota has become a major research area in
human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide …

One fungus, which genes? Development and assessment of universal primers for potential secondary fungal DNA barcodes

JB Stielow, CA Levesque, KA Seifert… - … and Evolution of …, 2015 - ingentaconnect.com
The aim of this study was to assess potential candidate gene regions and corresponding
universal primer pairs as secondary DNA barcodes for the fungal kingdom, additional to ITS …

Substrate-controlled succession of marine bacterioplankton populations induced by a phytoplankton bloom

H Teeling, BM Fuchs, D Becher, C Klockow… - Science, 2012 - science.org
Phytoplankton blooms characterize temperate ocean margin zones in spring. We
investigated the bacterioplankton response to a diatom bloom in the North Sea and …

Metagenomics-a guide from sampling to data analysis

T Thomas, J Gilbert, F Meyer - Microbial informatics and experimentation, 2012 - Springer
Metagenomics applies a suite of genomic technologies and bioinformatics tools to directly
access the genetic content of entire communities of organisms. The field of metagenomics …

MyTaxa: an advanced taxonomic classifier for genomic and metagenomic sequences

C Luo, LM Rodriguez-r… - Nucleic acids …, 2014 - academic.oup.com
Determining the taxonomic affiliation of sequences assembled from metagenomes remains
a major bottleneck that affects research across the fields of environmental, clinical and …

pplacer: linear time maximum-likelihood and Bayesian phylogenetic placement of sequences onto a fixed reference tree

FA Matsen, RB Kodner, EV Armbrust - BMC bioinformatics, 2010 - Springer
Background Likelihood-based phylogenetic inference is generally considered to be the most
reliable classification method for unknown sequences. However, traditional likelihood-based …

Statistical methods for detecting differentially abundant features in clinical metagenomic samples

JR White, N Nagarajan, M Pop - PLoS computational biology, 2009 - journals.plos.org
Numerous studies are currently underway to characterize the microbial communities
inhabiting our world. These studies aim to dramatically expand our understanding of the …