Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Fungi have proved to be a rich and important source of a huge number of secondary
metabolites with a large variety of chemical structures and diverse biological activities …

In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …

Conspectus Protein tyrosine phosphatases (PTPs) are essential signaling enzymes that,
together with protein tyrosine kinases, regulate tyrosine phosphorylation inside the cell …

Tuberculosis (TB) remains as a global pandemic that is aggravated by a lack of health care,
the spread of HIV, and the emergence of multidrug-resistant TB (MDR-TB) and extensively …

The use of an acetylene (ethynyl) group in medicinal chemistry coincides with the launch of
the Journal of Medicinal Chemistry in 1959. Since then, the acetylene group has been …

Das beste aus 40 000: Detaillierte Untersuchungen zur Struktur‐Aktivitäts‐Beziehung
enthüllten Schlüsselstrukturelemente von Indolin‐2‐on‐3‐spirothiazolidinonen (siehe …

Pathogenesis by mycobacteria requires the exploitation of host-cell signalling pathways to
enhance the intracellular survival and persistence of the pathogen. The disruption of these …

Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism for numerous
important aspects of eukaryotic physiology and is catalysed by kinases and phosphatases …