The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Perlecan, a large basement membrane heparan sulfate proteoglycan, is expressed in a
wide array of tissues where it regulates diverse cellular processes including bone formation …

Inflammation and autophagy have emerged as prominent issues in the context of
proteoglycan signaling. In particular, two small, leucine‐rich proteoglycans, biglycan and …

The extracellular matrix is a network of secreted macromolecules that provides a
harmonious meshwork for the growth and homeostatic development of organisms. It …

Acute myocardial infarction (AMI) accompanied by cardiac remodeling still lacks effective
treatment to date. Accumulated evidences suggest that exosomes from various sources play …

During tumor growth and angiogenesis there is a dynamic remodeling of tissue architecture
often accompanied by the release of extracellular matrix constituents full of biological …

Abstract Heparan sulfate proteoglycan 2 (HSPG2), also known as perlecan, is a large multi-
domain extracellular matrix proteoglycan, which contributes to the invasion, metastasis and …

Proteoglycans are rapidly emerging as versatile regulators of intracellular catabolic
pathways. This is predominantly achieved via the non-canonical induction of autophagy, a …

Whole heart engineering represents an incredible journey with as final destination the
challenging aim to solve end‐stage cardiac failure with a biocompatible and living organ …