Hypoxia can be defined as a relative deficiency in the amount of oxygen reaching the
tissues. Hypoxia-inducible factors (HIFs) are critical regulators of the mammalian response …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Hypoxia-inducible factors (HIFs) are best known for their roles in the adaptation to low
oxygen environments. Besides hypoxia, HIF-1/2 α-subunits are also regulated by various …

Feeding and growth are two closely related and important physiological processes in living
organisms. Studies in mammals have provided us with a series of characterizations of …

Objectives Hypothalamic dysfunction leads to glucose metabolic imbalance; however, the
mechanisms still need clarification. Our current study was to explore the role of hypothalamic …

We live and to do so we must breathe and eat, so are we a combination of what we eat and
breathe? Here, we will consider this question, and the role in this respect of the AMP …

Cellular metabolism is a complex network of biochemical reactions fueling development with
energy and biomass; however, it can also shape the cellular epigenome. Indeed, some …

The earliest hypoxia-inducible factor (HIF) function was to respond to hypoxia or hypoxic
conditions as a transcription factor. Recent studies have expanded our understanding of …

The hypothalamus is indispensable in energy regulation and glucose homeostasis.
Previous studies have shown that pro-opiomelanocortin neurons receive both central …

Objective This study aims to investigate whether hypoxia-inducible factor 1α (HIF1α) in the
neurons of the mediobasal hypothalamus is involved in the regulation of body weight …