Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

K Venkatesh, SK Ghosh, M Mullick… - Cell and tissue …, 2019 - Springer
Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Regeneration of spinal cord connectivity through stem cell transplantation and biomaterial scaffolds

H Katoh, K Yokota, MG Fehlings - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Significant progress has been made in the treatment of spinal cord injury (SCI). Advances in
post-trauma management and intensive rehabilitation have significantly improved the …

Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon

JW Rowland, GWJ Hawryluk, B Kwon, MG Fehlings - Neurosurgical focus, 2008 - thejns.org
This review summarizes the current understanding of spinal cord injury pathophysiology and
discusses important emerging regenerative approaches that have been translated into …

A systematic review of cellular transplantation therapies for spinal cord injury

W Tetzlaff, EB Okon, S Karimi-Abdolrezaee… - Journal of …, 2011 - liebertpub.com
Cell transplantation therapies have become a major focus in pre-clinical research as a
promising strategy for the treatment of spinal cord injury (SCI). In this article, we …

Schwann cell precursors from human pluripotent stem cells as a potential therapeutic target for myelin repair

HS Kim, J Lee, DY Lee, YD Kim, JY Kim, HJ Lim, S Lim… - Stem cell reports, 2017 - cell.com
Schwann cells play a crucial role in successful nerve repair and regeneration by supporting
both axonal growth and myelination. However, the sources of human Schwann cells are …

Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury

H Kanno, Y Pressman, A Moody, R Berg… - Journal of …, 2014 - Soc Neuroscience
Transplantation of Schwann cells (SCs) is a promising therapeutic strategy for spinal cord
repair. SCs introduced into lesions support axon regeneration, but because these axons do …

Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury

S Liu, B Sandner, T Schackel, LS Nicholson, A Chtarto… - Acta Biomaterialia, 2017 - Elsevier
Grafting of cell-seeded alginate capillary hydrogels into a spinal cord lesion site provides an
axonal bridge while physically directing regenerating axonal growth in a linear pattern …

The role of the serotonergic system in locomotor recovery after spinal cord injury

M Ghosh, DD Pearse - Frontiers in neural circuits, 2015 - frontiersin.org
Serotonin (5-HT), a monoamine neurotransmitter synthesized in various populations of
brainstem neurons, plays an important role in modulating the activity of spinal networks …

Schwann cell transplantation for spinal cord injury repair: its significant therapeutic potential and prospectus

H Kanno, DD Pearse, H Ozawa, E Itoi… - Reviews in the …, 2015 - degruyter.com
Abstract Transplantation of Schwann cells (SCs) is a promising therapeutic strategy for
spinal cord repair. The introduction of SCs into the injured spinal cord has been shown to …

Schwann cell-like cells: origin and usability for repair and regeneration of the peripheral and central nervous system

A Hopf, DJ Schaefer, DF Kalbermatten, R Guzman… - Cells, 2020 - mdpi.com
Functional recovery after neurotmesis, a complete transection of the nerve fiber, is often poor
and requires a surgical procedure. Especially for longer gaps (> 3 mm), end-to-end suturing …