Advanced glycation endproduct (AGE) formation is a trigger for the onset of age-related
disease. To evaluate AGE-induced change in the ocular fundus, 5-mo-old C57BL/6 mice …

Aging is associated with an increased incidence and severity of acute renal failure.
However, the molecular mechanism underlying the increased susceptibility to injury remains …

Elderly people exhibit a diminished capacity to cope with osmotic challenges such as
dehydration. We have undertaken a detailed molecular analysis of arginine vasopressin …

Aging is characterized by renal functional and structural abnormalities resembling those
observed in diabetes. These changes have been related to the progressive accumulation of …

Background Aging-related kidney diseases are a major health concern. Currently, models to
study renal aging are lacking. Due to a reduced life-span progeroid models hold the promise …

The importance of variance modelling is now widely known for the analysis of microarray
data. In particular the power and accuracy of statistical tests for differential gene expressions …

Aging kidney is associated in humans and rodents with polyuria and reduced urine
concentrating ability. In senescent female WAG/Rij rats, this defect is independent of …

Abstract p53 can induce apoptosis in various ways including transactivation, transrepression
and transcription-independent mechanisms. What determines the choice between them is …

In microarray experiments, accurate estimation of the gene variance is a key step in the
identification of differentially expressed genes. Variance models go from the too stringent …

Molecular markers of human aging Page 1 Genome-wide views of aging gene networks Stuart
Kim Depts. Developmental Biology/Genetics Stanford University Page 2 Human Aging …