Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …

Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …

Susceptibility to multiple autoimmune diseases is associated with common gene
polymorphisms influencing IL-2 signaling and T reg function, making T reg-specific …

Kidney transplantation has become a routine procedure in the treatment of patients with
kidney failure, and requires collaboration of experts from different disciplines, such as …

The limited penetration of nanoparticles in primary tumors and metastases remains a great
challenge for effective treatment of tumor metastasis. This review outlines the current …

Cell-based immunotherapies can provide safe and effective treatments for various disorders
including autoimmunity, cancer, and excessive proinflammatory events in sepsis or viral …

The use of chimeric antigen receptor (CAR)-engineered regulatory T cells (Tregs) has
emerged as a promising strategy to promote immune tolerance. However, in conventional T …

A cure for type 1 diabetes (T1D) would help millions of people worldwide but remains
elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary …

Chimeric antigen receptor (CAR) technology and its application to regulatory T cells (Tregs)
has garnered interest among researchers in the field of cell and gene therapy. Merging the …

Replacement therapy with factor VIII (FVIII) is used in patients with hemophilia A for
treatment of bleeding episodes or for prophylaxis. A common and serious problem with this …