Targeting and arginine-driven synergizing photodynamic therapy with nutritional immunotherapy nanosystems for combating MRSA biofilms
A Zhang, H Wu, X Chen, Z Chen, Y Pan, W Qu… - Science …, 2023 - science.org
The resistance and immune escape of methicillin-resistant Staphylococcus aureus (MRSA)
biofilms cause recalcitrant infections. Here, we design a targeting and synergizing cascade …
biofilms cause recalcitrant infections. Here, we design a targeting and synergizing cascade …
Exogenous fatty acids remodel Staphylococcus aureus lipid composition through fatty acid kinase
Staphylococcus aureus can utilize exogenous fatty acids for phospholipid synthesis. The
fatty acid kinase FakA is essential for this utilization by phosphorylating exogenous fatty …
fatty acid kinase FakA is essential for this utilization by phosphorylating exogenous fatty …
Elucidating the impact of bacterial lipases, human serum albumin, and FASII inhibition on the utilization of exogenous fatty acids by Staphylococcus aureus
EL Pruitt, R Zhang, DH Ross, NK Ashford, X Chen… - Msphere, 2023 - Am Soc Microbiol
Staphylococcus aureus only synthesizes straight-chain saturated fatty acids (SCFAs) or
branched-chain saturated fatty acids via the type II fatty acid synthesis (FASII) pathway, but …
branched-chain saturated fatty acids via the type II fatty acid synthesis (FASII) pathway, but …
[HTML][HTML] Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel …
AH Singleton, OET Bergum, CK Søgaard… - Frontiers in …, 2023 - frontiersin.org
The past few decades have been plagued by an increasing number of infections caused by
antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new …
antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new …
[HTML][HTML] Branched chain fatty acid synthesis drives tissue-specific innate immune response and infection dynamics of Staphylococcus aureus
X Chen, WP Teoh, MR Stock, ZJ Resko… - PLoS …, 2021 - journals.plos.org
Fatty acid-derived acyl chains of phospholipids and lipoproteins are central to bacterial
membrane fluidity and lipoprotein function. Though it can incorporate exogenous …
membrane fluidity and lipoprotein function. Though it can incorporate exogenous …
Genome-wide CRISPRi screens reveal the essentialome and determinants for susceptibility to dalbavancin in Staphylococcus aureus
X Liu, V de Bakker, MV Heggenhougen, MT Mårli… - bioRxiv, 2023 - biorxiv.org
Antibiotic resistance and tolerance remain a major problem for treatment of staphylococcal
infections. Knowing genes that influence antibiotic susceptibility could open the door to …
infections. Knowing genes that influence antibiotic susceptibility could open the door to …
Multiomics characterization of methicillin-resistant Staphylococcus aureus (MRSA) isolates with heterogeneous intermediate resistance to vancomycin (hVISA) in …
BE Castro, R Rios, LP Carvajal… - Journal of …, 2023 - academic.oup.com
Abstract Background Heterogeneous vancomycin-intermediate Staphylococcus aureus
(hVISA) compromise the clinical efficacy of vancomycin. The hVISA isolates spontaneously …
(hVISA) compromise the clinical efficacy of vancomycin. The hVISA isolates spontaneously …
The fadXDEBA locus of Staphylococcus aureus is required for metabolism of exogenous palmitic acid and in vivo growth
In Staphylococcus aureus, genes that should confer the capacity to metabolize fatty acids by
β‐oxidation occur in the fadXDEBA locus, but their function has not been elucidated …
β‐oxidation occur in the fadXDEBA locus, but their function has not been elucidated …
DNA Binding and Sensor Specificity of FarR, a Novel TetR Family Regulator Required for Induction of the Fatty Acid Efflux Pump FarE in Staphylococcus aureus
H Alnaseri, RC Kuiack, KA Ferguson… - Journal of …, 2019 - Am Soc Microbiol
Divergent genes in Staphylococcus aureus USA300 encode the efflux pump FarE and TetR
family regulator FarR, which confer resistance to antimicrobial unsaturated fatty acids. To …
family regulator FarR, which confer resistance to antimicrobial unsaturated fatty acids. To …
Inactivation of the exogenous fatty acid utilization pathway leads to increased resistance to unsaturated fatty acids in Staphylococcus aureus
The human pathogen Staphylococcus aureus produces saturated fatty acids, but can
incorporate both exogenous saturated and unsaturated fatty acids into its lipid membrane. S …
incorporate both exogenous saturated and unsaturated fatty acids into its lipid membrane. S …