Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their
flexible organization and functional redundancies make deciphering their sequence-function …

Gene expression is regulated by transcription factors that work together to read cis-
regulatory DNA sequences. The 'cis-regulatory code'—how cells interpret DNA sequences …

Genomes encode for genes and non-coding DNA, both capable of transcriptional activity.
However, unlike canonical genes, many transcripts from non-coding DNA have limited …

Pervasive transcriptional activity is observed across diverse species. The genomes of extant
organisms have undergone billions of years of evolution, making it unclear whether these …

Although the majority of annotated new genes in a given genome appear to have arisen
from duplication-related mechanisms, recent studies have shown that genes can also …

Regulatory DNA sequences within enhancers and promoters bind transcription factors to
encode cell type-specific patterns of gene expression. However, the regulatory effects and …

Transcription factor combinations play a key role in shaping cellular identity. However, the
precise relationship between specific combinations and downstream effects remains …

Our understanding of how cis-regulatory elements work has advanced rapidly, outpacing
our evolutionary models. In this review, we consider the implications of new mechanistic …

Understanding the evolutionary potential of mutations in gene regulatory networks is
essential to furthering the study of evolution and development. However, in multicellular …

Rapid enhancer and slow promoter evolution have been demonstrated through comparative
genomics. However, it is not clear how this information is encoded genetically and if this can …