Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

In biological environments, nanoparticles are enshrouded by a layer of biomolecules,
predominantly proteins, mediating its subsequent interactions with cells. Detecting this …

Amyloid fibrillation of proteins is associated with a great variety of pathologic conditions.
Development of new molecules that can monitor amyloidosis kinetics and inhibit fibril …

We report the detailed mechanical characterization of individual amyloid fibrils by atomic
force microscopy and spectroscopy. These self-assembling materials, formed here from the …

In the rare medical condition termed injection amyloidosis, extracellular fibrils of insulin are
observed. We found that the segment of the insulin B-chain with sequence LVEALYL is the …

Protein-nanoparticle interactions are of central importance in the biomedical applications of
nanoparticles, as well as in the growing biosafety concerns of nanomaterials. We observe …

Dark days for diabetic patients were transformed into an era of hope when the therapeutic
usage of insulin was discovered. However, those initial glory days changed to being …

The physicochemical parameters of biomolecules are the key determinants of the multitude
of processes that govern the normal and aberrant behavior of living systems. A particularly …

The formation of insulin amyloid can dramatically impact glycemic control in patients with
diabetes, making it an important therapeutic consideration. In addition, the cost associated …

The self-assembly of proteins and peptides into polymeric amyloid fibrils is a process that
has important implications ranging from the understanding of protein misfolding disorders to …