Neuronal growth cones navigate over long distances along specific pathways to find their
correct targets. The mechanisms and molecules that direct this pathfinding are the topics of …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

We have identified three members of a mouse gene family related to the Drosophila
segment polarity gene, hedgehog (h/t). Like h/t, they encode putative secreted proteins and …

During nervous system development, spinal commissural axons project toward floor plate
cells and trochlear motor axons extend away from these cells. Netrin-1, a diffusible protein …

In vertebrates, commissural axons pioneer a clrcumferentlal pathway to the floor plate at the
ventral midline of the embryonic spinal cord. Floor plate cells secrete a diffusible factor that …

The guidance of axons to their targets in the developing nervous system is believed to
involve dlffuslble chemotroplc factors secreted by target cells. Floor plate cells at the ventral …

The guidance of developing axons in the nervous system is mediated partly by diffusible
chemoattractants secreted by axonal target cells. Netrins are chemoattractants for …

The functioning of the nervous system depends upon the underlying detailed and highly
stereotyped patterns of neuronal connectivity. How these precise patterns of synaptic …

The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-
suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have …

Developing axons are guided to their targets by attractive and repulsive guidance cues. In
the embryonic spinal cord, the floor plate chemoattractant Netrin-1 is required to guide …