Current drugs for HIV-1: from challenges to potential in HIV/AIDS
Y Peng, Y Zong, D Wang, J Chen, ZS Chen… - Frontiers in …, 2023 - frontiersin.org
The human immunodeficiency virus (HIV) persists in latently infected CD4+ T cells and
integrates with the host genome until cell death. Acquired immunodeficiency syndrome …
integrates with the host genome until cell death. Acquired immunodeficiency syndrome …
Novel computational and drug design strategies for inhibition of human papillomavirus-associated cervical cancer and DNA polymerase theta receptor by Apigenin …
The present study deals with the advanced in-silico analyses of several Apigenin derivatives
to explore human papillomavirus-associated cervical cancer and DNA polymerase theta …
to explore human papillomavirus-associated cervical cancer and DNA polymerase theta …
Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence …
Background Ethiopia is among the highly HIV-affected countries, with reported 12,000 and
12,000 AIDS-related deaths and incidents as per reports from 2021. Although the country …
12,000 AIDS-related deaths and incidents as per reports from 2021. Although the country …
Computational exploration of natural compounds targeting Staphylococcus aureus: inhibiting AgrA promoter binding for antimicrobial intervention
Staphylococcus aureus is a highly virulent nosocomial pathogen that poses a significant
threat to individuals exposed to healthcare settings. Due to its sophisticated machinery for …
threat to individuals exposed to healthcare settings. Due to its sophisticated machinery for …
Development and emerging trends of drug resistance mutations in HIV: a bibliometric analysis based on CiteSpace
X Chen, X Chen, Y Lai - Frontiers in Microbiology, 2024 - frontiersin.org
Background Antiretroviral therapy has led to AIDS being a chronic disease. Nevertheless,
the presence of constantly emerging drug resistance mutations poses a challenge to clinical …
the presence of constantly emerging drug resistance mutations poses a challenge to clinical …
Rutin potentially binds the gamma secretase catalytic site, down regulates the notch signaling pathway and reduces sphere formation in colonospheres
Rutin, a natural flavonol, can modulate molecular signaling pathways and has considerable
potential in cancer treatment. However, little is known about the effect of rutin on the notch …
potential in cancer treatment. However, little is known about the effect of rutin on the notch …
Hesperidin potentially interacts with the catalytic site of gamma-secretase and modifies notch sensitive genes and cancer stemness marker expression in colon cancer …
Gamma secretase (GS) produces Notch Intracellular Domain (NICD) by trans-membrane
cleavage of notch receptor. The NICD enters the nucleus and activates the notch signaling …
cleavage of notch receptor. The NICD enters the nucleus and activates the notch signaling …
Discovery of anticancer compound possessing potential to bind γ-secretase catalytic subunit and inhibit notch promoter activity
AK Singh, KS Prajapati, S Kumar - Journal of Biomolecular …, 2024 - Taylor & Francis
Gamma secretase (GS) is an important therapeutic target in anticancer drug discovery.
Increased GS activity activates notch signaling pathway which is associated with cancer …
Increased GS activity activates notch signaling pathway which is associated with cancer …
Identification and molecular docking of novel chikungunya virus NSP4 inhibitory peptides from camel milk proteins
HI Alguridi, F Alzahrani, S Almalki… - Journal of …, 2023 - Taylor & Francis
The chikungunya (CHIK) virus is an arbovirus belonging to the alphavirus (Togaviridae
family). Around 85% of infected individuals suffer from symptoms such as high fever and …
family). Around 85% of infected individuals suffer from symptoms such as high fever and …
Synthesis of novel (R)-carvone-tagged thiazolidinone as anticancer leads: characterization, in vitro antiproliferative evaluation and in silico studies
This work describes the successful synthesis of a series of three novel thiazolidinone-
carvone-O-alkyl hybrids through a two-step approach involving heterocyclization and O …
carvone-O-alkyl hybrids through a two-step approach involving heterocyclization and O …