Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown
mechanisms, induce widespread inflammation. We found that a large proportion of primary …

In order to investigate the relationship between airways inflammation and disease severity,
and improve the understanding of persistent asthma, 74 asthmatics, with disease severity …

Using a combined pharmacological and gene-deletion approach, we have delineated a
novel mechanism of neurokinin-1 (NK-1) receptor-dependent hyperalgesia induced by …

Mast cells (MCs) are traditionally thought of as a nuisance for its host, for example, by
causing many of the symptoms associated with allergic reactions. In addition, recent …

Disruption of the blood–brain-barrier (BBB) is important in the pathophysiology of various
inflammatory conditions of the central nervous system (CNS), such as multiple sclerosis …

Mast cells (MCs) are active participants in blood coagulation and innate and acquired
immunity. This review focuses on the development of mouse and human MCs, as well as the …

Mast cells (MC s) play a central role in tissue homoeostasis, sensing the local environment
through numerous innate cell surface receptors. This enables them to respond rapidly to …

Cystitis, or inflammation of the bladder, has a direct effect on bladder function. Interstitial
cystitis is a syndrome characterized by urinary bladder pain and irritative symptoms of more …