Reactive oxygen species (ROS) are well known for their role in mediating both physiological
and pathophysiological signal transduction. Enzymes and subcellular compartments that …

Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Reductions in the blood supply produce considerable injury if the duration of ischemia is
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …

The major energy generator in the cell–mitochondria produce reactive oxygen species as a
by-product of a number of enzymatic reactions and the production of ATP. Emerging …

Abstract See Jellinger (doi: 10.1093/awx190) for a scientific commentary on this article. The
enzyme monoamine oxidases (B and A subtypes, encoded by MAOB and MAOA …

Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for
treatment of depression and other neurological disorders. Evidence has suggested that …

Synucleinopathies are a group of neurodegenerative disorders caused by the accumulation
of toxic species of α-synuclein. The common clinical features are chronic progressive …

Several neurodegenerative diseases involve loss of catecholamine neurons—Parkinson
disease is a prototypical example. Catecholamine neurons are rare in the nervous system …

It would not be practical to attempt to deal with all the advances that have informed our
understanding of the behavior and functions of this enzyme over the past 90 years. This …

Monoamine oxidase types A and B (MAO-A, MAO-B) regulate the levels of monoamine
neurotransmitters in the brain, and their dysfunction may be involved in the pathogenesis …